Zhenkun Wu
Hunan University
28 Papers
41 Citations
Zhenkun Wu is an academic researcher from Hunan University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 8, co-authored 14 publications. Previous affiliations of Zhenkun Wu include University of Illinois at Urbana–Champaign.
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Papers
Highly Sensitive and Selective Strategy for MicroRNA Detection Based on WS2 Nanosheet Mediated Fluorescence Quenching and Duplex-Specific Nuclease Signal Amplification
TL;DR: WS2 nanosheet can exhibit differential affinity toward short oligonucleotide fragment versus ssDNA probe and act as an efficient quencher for adsorbed fluorescent probes and indicates that this simple and cost-effective strategy holds great potential application in biomedical research and clinical diagnostics.
367
Imaging Endogenous Metal Ions in Living Cells Using a DNAzyme-Catalytic Hairpin Assembly Probe.
Zhenkun Wu,Zhenkun Wu,Huanhuan Fan,Huanhuan Fan,Nitya Sai Reddy Satyavolu,Wenjing Wang,Wenjing Wang,Ryan J. Lake,Jian-Hui Jiang,Yi Lu +9 more
TL;DR: The design of a catalytic hairpin assembly (CHA) reaction to amplify the signal from photocaged Na+ -specific DNAzyme to detect endogenous Na+ inside cells is reported to contribute to deeper understanding of the role of metal ions in biological systems.
Near‐Infrared Photothermally Activated DNAzyme–Gold Nanoshells for Imaging Metal Ions in Living Cells
Wenjing Wang,Wenjing Wang,Nitya Sai Reddy Satyavolu,Zhenkun Wu,Zhenkun Wu,Jian Rong Zhang,Jun-Jie Zhu,Yi Lu +7 more
TL;DR: This method has expanded the DNAzyme versatility for detecting metal ions in biological systems under NIR light that exhibits lower phototoxicity and higher tissue penetration ability.
187
Activity-Based DNA-Gold Nanoparticle Probe as Colorimetric Biosensor for DNA Methyltransferase/Glycosylase Assay
TL;DR: The results reveal that the colorimetric response increases dynamically with increasing activity of the enzymes, implying a great potential of this strategy for DNA methyltransferase/glycosylase detection and molecular diagnostics and drug screening.
138
Protein scaffolded DNA tetrads enable efficient delivery and ultrasensitive imaging of miRNA through crosslinking hybridization chain reaction.
TL;DR: DNA tetrads as an integrated platform that enables realization of efficient DNA delivery and HCR amplification in situ on nanostructures.