Zhengshi Lin
Center for Biologics Evaluation and Research
10 Papers
77 Citations
Zhengshi Lin is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Vaccination & Influenza A virus. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Zhengshi Lin include Food and Drug Administration.
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Papers
H3N2 Mismatch of 2014–15 Northern Hemisphere Influenza Vaccines and Head-to-head Comparison between Human and Ferret Antisera derived Antigenic Maps
Hang Xie,Xiu-Feng Wan,Zhiping Ye,Ewan P. Plant,Yangqing Zhao,Yifei Xu,Xing Li,Courtney Finch,Nan Zhao,Toshiaki Kawano,Olga Zoueva,Meng-Jung Chiang,Xianghong Jing,Zhengshi Lin,Anding Zhang,Yanhong Zhu +15 more
TL;DR: Molecular modeling indicated that the mutations of epidemic H3 strains were mainly located in antibody-binding sites A and B as compared with TX/12e, and human serologic testing on vaccination-induced cross-reactivity need be emphasized along with virus antigenic characterization by ferret model.
Immunogenicity and Cross-Reactivity of 2009–2010 Inactivated Seasonal Influenza Vaccine in US Adults and Elderly
TL;DR: The campaign of 2009–2010 Northern Hemisphere seasonal vaccination was concurrent with the 2009 H1N1 pandemic and the pandemic specific cross-reactive antibodies strongly correlated with the post-vaccination HAI titers against the seasonal H3N2 vaccine strain in all subjects.
Revisiting the 1976 “Swine Flu” Vaccine Clinical Trials: Cross-reactive Hemagglutinin and Neuraminidase Antibodies and Their Role in Protection Against the 2009 H1N1 Pandemic Virus in Mice
Hang Xie,Xing Li,Jin Gao,Zhengshi Lin,Xianghong Jing,Ewan P. Plant,Olga Zoueva,Maryna C. Eichelberger,Zhiping Ye +8 more
TL;DR: The 1976 swine flu vaccination induced cross-reactive HAI and NAI antibodies that were functionally protective in mice, suggesting that this vaccination campaign might have had a positive impact on older adults (≥50 years) in the United States during the 2009 H1N1 pandemic.
Different Circulation Pattern of Multiple Respiratory Viruses in Southern China During the COVID-19 Pandemic
Zhiqi Zeng,Wenda Guan,Yong Liu,Zhengshi Lin,Wenhua Liang,Jingyi Liang,Bingqian Chen,Tong Wu,Yutao Wang,Chunguang Yang,Qiubao Wu,Zhitong Mai,Jin-min Zhou,Jun Bo Zhou,Zhoulang Wang,Zhijie Lin,Chun-xiang Hu,Chunqiu Wu,Pengyuan Zhu,Canxiong Chen,Nanshan Zhong,Eric H. Y. Lau,Chi Ho Ivan Hon,Yaoming Liang,Zifeng Yang,Jianxing He +25 more
TL;DR: It is found that while the overall activity of respiratory viruses was lower during the period with stringent NPIs, virus activity rebounded shortly after the NPIs were relaxed and social activities resumed, showing that NPIs against COVID-19 have different impacts on respiratory viruses.
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Maintaining pH-dependent conformational flexibility of M1 is critical for efficient influenza A virus replication.
Meng-Jung Chiang,Faik N. Musayev,Martina Kosikova,Zhengshi Lin,Yamei Gao,Philip D. Mosier,Bashayer Althufairi,Zhiping Ye,Qibing Zhou,Umesh R. Desai,Hang Xie,Martin K. Safo +11 more
TL;DR: The results suggest that maintaining M1 pH-dependent conformational flexibility is critical for efficient virus replication, and position 88 is a key residue controlling M 1 pH- dependent conformational changes.
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