Zhengfeng Zhou
University of Wisconsin-Madison
14 Papers
492 Citations
Zhengfeng Zhou is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: hERG & Potassium channel. The author has an hindex of 13, co-authored 14 publications.
Chat about Author
Papers
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.
Zhengfeng Zhou,Qiuming Gong,Bin Ye,Zheng Fan,Jonathan C. Makielski,Gail A. Robertson,Craig T. January +6 more
TL;DR: The data support the postulate that HERG encodes a major constituent of I(Kr) and suggest that at physiological temperatures HERG contributes current throughout most of the action potential and into the postrepolarization period.
786
Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome. Pharmacological and temperature effects.
TL;DR: It is shown that the N470D LQT2 mutant protein is trafficking-deficient when expressed at 37’°C in HEK293 cells, whereas at 27 °C its trafficking to the plasma membrane and channel function are markedly improved, suggesting that protein misfolding leading to defective trafficking of some HERG LqT mutations may be corrected by specific pharmacological strategies.
318
Novel mechanism associated with an inherited cardiac arrhythmia: defective protein trafficking by the mutant HERG (G601S) potassium channel.
Michiko Furutani,Matthew C. Trudeau,Nobuhisa Hagiwara,Akiko Seki,Qiuming Gong,Zhengfeng Zhou,Shin Ichiro Imamura,Hirotaka Nagashima,Hiroshi Kasanuki,Atsuyoshi Takao,Kazuo Momma,Craig T. January,Gail A. Robertson,Rumiko Matsuoka +13 more
TL;DR: The results from both the Xenopus oocyte and HEK293 cell expression systems and green fluorescent protein tagging and Western blot analyses support the conclusion that the G601S mutant is a hypomorphic mutation, resulting in a reduced current amplitude, which represents a novel mechanism underlying LQT2.
199
Droperidol Lengthens Cardiac Repolarization due to Block of the Rapid Component of the Delayed Rectifier Potassium Current
Benoit Drolet,Shetuan Zhang,Dominic Deschênes,Jimmy Rail,Sylvie Nadeau,Zhengfeng Zhou,Craig T. January,Jacques Turgeon +7 more
TL;DR: The effects of droperidol on cardiac repolarization are characterized and a major time‐dependent outward potassium current involved in cardiacRepolarization (IKr) is evaluated.
124
Long QT syndrome: cellular basis and arrhythmia mechanism in LQT2.
TL;DR: Current findings about mutations causing LQT2, the mechanisms by which mutations may cause the clinical phenotype of a reduction in IKr and a prolonged QT interval, and how this may be involved in the generation of ventricular arrhythmias are summarized.
110