Zhengfan Jiang
Peking University
99 Papers
280 Citations
Zhengfan Jiang is an academic researcher from Peking University. The author has contributed to research in topics: Innate immune system & Biology. The author has an hindex of 43, co-authored 93 publications. Previous affiliations of Zhengfan Jiang include Cleveland Clinic & Scripps Research Institute.
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Papers
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
Wenxiang Sun,Yang Li,Lu Chen,Huihui Chen,Fuping You,Xiang Zhou,Yi Zhou,Zhonghe Zhai,Danying Chen,Zhengfan Jiang +9 more
TL;DR: The identification and characterization of a protein, ERIS, an endoplasmic reticulum (ER) IFN Stimulator, which is a strong type I IFN stimulator and plays a pivotal role in response to both non–self-cytosolic RNA and dsDNA is reported.
836
Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large
Bruce Beutler,Zhengfan Jiang,Philippe Georgel,Karine Crozat,Ben A. Croker,Sophie Rutschmann,Xin Du,Kasper Hoebe +7 more
TL;DR: The positional cloning of a spontaneous mutation that caused lipopolysaccharide resistance and susceptibility to Gram-negative infection led directly to the understanding that Toll-like receptors (TLRs) are essential sensors of microbial infection.
830
CD14 is required for MyD88-independent LPS signaling
Zhengfan Jiang,Philippe Georgel,Xin Du,Louis Shamel,Sosathya Sovath,Suzanne Mudd,Michael Huber,Christoph Kalis,Simone Keck,Chris Galanos,Marina A. Freudenberg,Bruce Beutler +11 more
TL;DR: The recessive mutation 'Heedless' (hdl) was detected in third-generation N-ethyl-N-nitrosourea–mutated mice that showed defective responses to microbial inducers, and the data suggest that the TLR4–MD-2 complex distinguishes LPS chemotypes, but CD14 nullifies this distinction.
736
Manganese is critical for antitumor immune responses via cGAS-STING and improves the efficacy of clinical immunotherapy
Mengze Lv,Mengze Lv,Meixia Chen,Rui Zhang,Wen Zhang,Wen Zhang,Chenguang Wang,Yan Zhang,Xiaoming Wei,Yukun Guan,Yukun Guan,Jiejie Liu,Kaichao Feng,Miao Jing,Xurui Wang,Yun-Cai Liu,Qian Mei,Weidong Han,Zhengfan Jiang +18 more
TL;DR: A completed phase 1 clinical trial with the combined regimen of Mn2+ and anti-PD-1 antibody showed promising efficacy, exhibiting type I IFN induction, manageable safety and revived responses to immunotherapy in most patients with advanced metastatic solid tumors.
Manganese Increases the Sensitivity of the cGAS-STING Pathway for Double-Stranded DNA and Is Required for the Host Defense against DNA Viruses
Chenguang Wang,Yukun Guan,Mengze Lv,Rui Zhang,Zhaoying Guo,Xiaoming Wei,Xiao-Xia Du,Jing Yang,Tong Li,Yi Wan,Xiao-Dong Su,Xiao-Jun Huang,Zhengfan Jiang +12 more
TL;DR: It is found that upon virus infection, Manganese (Mn2+) is released from organelles into the cytosol and facilitates the activation of cGAS and STING.
552