Zhengchen Su
University of Texas Medical Branch
13 Papers
6 Citations
Zhengchen Su is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Endothelial stem cell & Ebola virus. The author has an hindex of 4, co-authored 13 publications.
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Papers
Cell-type apoptosis in lung during SARS-CoV-2 infection
Yakun Liu,Tania Garron,Qing Chang,Zhengchen Su,Changcheng Zhou,Eric C Gong,Junying Zheng,Yw Yin,Thomas G. Ksiazek,Trevor Brasel,Yang Jin,Paul J. Boor,Jason E. Comer,Bin Gong +13 more
TL;DR: In this paper, the authors examined apoptosis in post-mortem lung sections from COVID-19 patients and lung tissues from a nonhuman primate model of SARS-CoV-2 infection, in a cell-type manner, including type 1 and 2 alveolar cells and vascular endothelial cells (ECs), macrophages, and T cells.
Host EPAC1 Modulates Rickettsial Adhesion to Vascular Endothelial Cells via Regulation of ANXA2 Y23 Phosphorylation
Zhengchen Su,Thomas R. Shelite,Yuan Qiu,Qing Chang,Maki Wakamiya,Jiani Bei,Xi He,Changcheng Zhou,Yakun Liu,Emmanuel Nyong,Yuejin Liang,Angelo Gaitas,Tais B. Saito,Bin Gong +13 more
TL;DR: In this paper, the functional role of the EPAC1-ANXA2 signaling pathway during initial adhesion of rickettsiae to EC surfaces was dissected using fluidic force microscopy (FluidFM).
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EPAC regulates von Willebrand factor secretion from endothelial cells in a PI3K/eNOS-dependent manner during inflammation.
Jie Xiao,Ben Zhang,Zhengchen Su,Yakun Liu,Thomas R. Shelite,Qing Chang,Pingyuan Wang,Alexander Bukreyev,Lynn Soong,Yang Jin,Thomas G. Ksiazek,Angelo Gaitas,Shannan L. Rossi,Jia Zhou,Michael Laposata,Tais B. Saito,Bin Gong +16 more
TL;DR: A novel regulatory role of EPAC1 in vWF secretion is delineated and light is shed on potential development of new strategies to controlling thrombosis during inflammation.
Annexin A2 depletion exacerbates the intracerebral microhemorrhage induced by acute rickettsia and Ebola virus infections
Zhengchen Su,Qing Chang,Aleksandra Drelich,Thomas R. Shelite,Barbara M. Judy,Yakun Liu,Jie Xiao,Changchen Zhou,Xi He,Taís Berelli Saito,Shao Jun Tang,Lynn Soong,Maki Wakamiya,Xiang Fang,Alexander Bukreyev,Thomas G. Ksiazek,William K. Russell,Bin Gong +17 more
TL;DR: It is reported that ANxA2-knockout (KO) mice are more susceptible to CMHs in response to rickettsia and Ebola virus infections, suggesting an essential role of ANXA2 in protecting vascular integrity during these intracellular pathogen infections.
Host EPAC1 modulates rickettsial adhesion to vascular endothelial cells via regulation of ANXA2 Y23 phosphorylation
Zhengchen Su,Thomas R. Shelite,Yuan Qiu,Qing Chang,Maki Wakamiya,Jiani Bei,Xi He,Changcheng Zhou,Yakun Liu,Angelo Gaitas,Tais B. Saito,Bin Gong +11 more
TL;DR: In this paper, the role of EPAC1-ANXA2 signaling pathway in the regulation of rickettsial adhesion to ECs was investigated using fluidic force microscopy (FluidFM) and single living brain microvascular EC study.