Zheng Wang
University of Iowa
4 Papers
45 Citations
Zheng Wang is an academic researcher from University of Iowa. The author has contributed to research in topics: Receptor & Phorbol. The author has an hindex of 4, co-authored 4 publications.
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Papers
Phosphorylation of the Lutropin/Choriogonadotropin Receptor Facilitates Uncoupling of the Receptor from Adenylyl Cyclase and Endocytosis of the Bound Hormone
TL;DR: Results show that phosphorylation of rLHR is necessary, but not sufficient, for uncoupling of the receptors from adenylyl cyclase and for endocytosis of the receptor-bound hormone.
Mutation of a highly conserved acidic residue present in the second intracellular loop of G-protein-coupled receptors does not impair hormone binding or signal transduction of the luteinizing hormone/chorionic gonadotropin receptor.
TL;DR: An E441Q or an E441D mutation in the LH/CG receptor results in only a slight increase in the EC50 for cAMP accumulation without decreasing the maximal response attained, the most remarkable effect of these mutations was on localization of the receptor.
Progressive cytoplasmic tail truncations of the lutropin-choriogonadotropin receptor prevent agonist- or phorbol ester-induced phosphorylation, impair agonist- or phorbol ester-induced desensitization, and enhance agonist-induced receptor down-regulation.
TL;DR: Results clearly show that residues 632-653 in the C-terminal tail of the rLHR are involved in PMA-induced desensitization, hCG-induced de-sensitizedness, and h CG-induced down-regulation.
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Human chorionic gonadotropin (CG)- and phorbol ester-stimulated phosphorylation of the luteinizing hormone/CG receptor maps to serines 635, 639, 649, and 652 in the C-terminal cytoplasmic tail.
TL;DR: The experiments presented here show that although hCG activates the C kinase in these cells, phosphorylation of the LH/CG receptor in response to hCG is maintained in C Kinase-deficient cells, suggesting that activation of protein kinase C is not required for hCG-induced phosphorylations of its receptor.