Zheng Wang
Duke University
10 Papers
76 Citations
Zheng Wang is an academic researcher from Duke University. The author has contributed to research in topics: Netrin & Invadopodia. The author has an hindex of 8, co-authored 10 publications. Previous affiliations of Zheng Wang include Huazhong University of Science and Technology.
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Papers
Cell Invasion In Vivo via Rapid Exocytosis of a Transient Lysosome-Derived Membrane Domain.
Kaleb M. Naegeli,Eric Hastie,Aastha Garde,Zheng Wang,Daniel P. Keeley,Kacy L. Gordon,Ariel M. Pani,Laura C. Kelley,Meghan A. Morrissey,Qiuyi Chi,Bob Goldstein,David R. Sherwood +11 more
TL;DR: A netrin-dependent pathway that builds an invasive protrusion, an isolated lysosome-derived membrane structure specialized to breach tissue barriers is defined.
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Live-cell confocal microscopy and quantitative 4D image analysis of anchor-cell invasion through the basement membrane in Caenorhabditis elegans.
Laura C. Kelley,Zheng Wang,Zheng Wang,Elliott J. Hagedorn,Lin Wang,Wanqing Shen,Shijun Lei,Sam A. Johnson,David R. Sherwood +8 more
TL;DR: This protocol describes multichannel time-lapse confocal imaging of anchor-cell invasion in live Caenorhabditis elegans and can be combined with genetic analysis, molecular-activity probes and optogenetic approaches to uncover the molecular mechanisms underlying cell invasion.
ADF/cofilin promotes invadopodial membrane recycling during cell invasion in vivo
TL;DR: Localized F-actin disassembly by ADF/cofilin drives invadopodial membrane recycling through endolysosomes, which promotes efficient cell transmigration through the basement membrane.
Dissection of genetic pathways in C. elegans.
Zheng Wang,David R. Sherwood +1 more
TL;DR: An overview of the approaches available to identify and construct the genetic pathways using C. elegans is provided to gain a more complete understanding of how gene regulatory networks control a particular biological process.
MIG-10 (lamellipodin) has netrin-independent functions and is a FOS-1A transcriptional target during anchor cell invasion in C. elegans
TL;DR: MIG-10 has distinct functions from UNC-40 signaling in cell invasion, and it is demonstrated that integrin coordinates invasion by localizing these molecules to the cell-basement membrane interface.