Zhen Yang
Emory University
5 Papers
Zhen Yang is an academic researcher from Emory University. The author has contributed to research in topics: Withaferin A & Fatty acid synthase. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Zhen Yang include Washington University in St. Louis.
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Papers
Pulmonary ozone exposure induces vascular dysfunction, mitochondrial damage, and atherogenesis
Gin C. Chuang,Zhen Yang,David G. Westbrook,Melissa Pompilius,Carol A. Ballinger,C. Roger White,David M. Krzywanski,Edward M. Postlethwait,Scott W. Ballinger +8 more
TL;DR: It is revealed that ozone increased vascular mtDNA damage in nonhuman primates in a fashion consistent with known atherosclerotic lesion susceptibility in humans, and inhaled ozone, in the absence of other environmental toxicants, promotes increased vascular dysfunction, oxidative stress, mitochondrial damage, and atherogenesis.
Macrophage Fatty-acid Synthase Deficiency Decreases Diet-induced Atherosclerosis
Jochen G. Schneider,Zhen Yang,Manu V. Chakravarthy,Irfan J. Lodhi,Xiaochao Wei,John Turk,Clay F. Semenkovich +6 more
TL;DR: Results show that macrophage FAS deficiency decreases atherosclerosis through induction of LXR α and suggest that FAS, which is induced by LXRα, may generate regulatory lipids that cause feedback inhibition of NXRα in macrophages.
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Withania somnifera root extract inhibits mammary cancer metastasis and epithelial to mesenchymal transition.
Zhen Yang,Anapatricia Garcia,Songli Xu,Doris R. Powell,Paula M. Vertino,Shivendra V. Singh,Adam I. Marcus +6 more
TL;DR: In both models, sWRE and Withaferin A showed dose-dependent inhibition of tumor growth and metastatic lung nodule formation with minimal systemic toxicity, suggesting the potential for clinical use of orally administered WRE capsules.
Fatty Acid Synthase Modulates Intestinal Barrier Function through Palmitoylation of Mucin 2
Xiaochao Wei,Zhen Yang,Federico E. Rey,Vanessa K. Ridaura,Nicholas O. Davidson,Jeffrey I. Gordon,Clay F. Semenkovich +6 more
TL;DR: The role of FAS in maintaining intestinal barrier function may explain the pathogenesis of intestinal inflammation in diabetes and other disorders.
Growth arrest by the antitumor steroidal lactone withaferin a in human breast cancer cells is associated with down-regulation and covalent binding at cysteine 303 of β-tubulin
Marie Lue Antony,Joomin Lee,Eun-Ryeong Hahm,Su Hyeong Kim,Adam I. Marcus,Vandana Kumari,Xinhua Ji,Zhen Yang,Courtney L. Vowell,Peter Wipf,Guy Uechi,Nathan A. Yates,Guillermo Romero,Saumendra N. Sarkar,Shivendra V. Singh +14 more
TL;DR: It is reported that tubulin is a novel target of WA-mediated growth arrest in human breast cancer cells, and NMR analyses revealed that the A-ring enone in WA, but not in withanone or withanolide A, was highly reactive with cysteamine and rapidly succumbed to irreversible nucleophilic addition.