Zhen Li
Shandong University
10 Papers
2 Citations
Zhen Li is an academic researcher from Shandong University. The author has contributed to research in topics: Hepatic stellate cell & Fibrosis. The author has an hindex of 5, co-authored 9 publications.
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Papers
Carvedilol attenuates liver fibrosis by suppressing autophagy and promoting apoptosis in hepatic stellate cells.
TL;DR: Evidence is found that carvedilol suppresses autophagy and promotes apoptosis in HSCs and the late-stage inhibition of Autophagy preceded the induction of apoptosis, and evidence that carvedILol inhibited autophagic flux by increasing lysosomal pH and not by impairing the fusion of autophagosomes with lysOSomes.
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Carvedilol attenuates carbon tetrachloride-induced liver fibrosis and hepatic sinusoidal capillarization in mice.
TL;DR: It is demonstrated that carvedilol could prevent further development of liver fibrosis and hepatic sinusoidal capillarization in mice with CCl4-induced fibrosis.
Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase.
TL;DR: Metformin attenuates the fibrogenic response of HSCs in vivo and in vitro, and may therefore be useful for the treatment of chronic liver diseases.
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Carvedilol Inhibits Angiotensin II-Induced Proliferation and Contraction in Hepatic Stellate Cells through the RhoA/Rho-Kinase Pathway
TL;DR: It is indicated that carvedilol dose-dependently inhibited Ang II-induced HSC proliferation by impeding cell cycle progression, thus alleviating hepatic fibrosis and interfering with the AT1R-mediated RhoA/ROCK2 pathway.
Carvedilol improves liver cirrhosis in rats by inhibiting hepatic stellate cell activation, proliferation, invasion and collagen synthesis
TL;DR: Carvedilol may alleviate liver cirrhosis in rats by inhibiting HSC activation, proliferation, invasion and collagen synthesis, and may be a potential treatment of early-stage liver Cirrhosis.