Zhen-Hui Sun
8 Papers
Zhen-Hui Sun is an academic researcher. The author has contributed to research in topics: Medicine & Gene knockdown. The author has an hindex of 1, co-authored 1 publications.
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Papers
WTAP-mediated m6A modification modulates bone marrow mesenchymal stem cells differentiation potential and osteoporosis
TL;DR: In this paper , the role of Wilms' tumor 1-associated protein (WTAP), a member of the m6A functional protein family, in regulating BMSCs differentiation remains unknown.
Arginine methylation of PPP1CA by CARM1 regulates glucose metabolism and affects osteogenic differentiation and osteoclastic differentiation
Lu Zhang,Guangjun Jiao,Yu Cui You,Xiang Li,Jincheng Liu,Zhen-Hui Sun,Qinghui Li,Zihan Dai,Jinlong Ma,Hongming Zhou,Gang Li,Chunyang Meng,Yun-Xia Chen +12 more
TL;DR: It is discovered that CARM1 reprogrammed glucose metabolism in osteoblasts and osteoclasts from oxidative phosphorylation to aerobic glycolysis, thereby promoting osteogenic differentiation and inhibiting osteoclastic differentiation.
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WTAP-Mediated m6A RNA Methylation Regulates the Differentiation of Bone Marrow Mesenchymal Stem Cells via the miR-29b-3p/HDAC4 Axis
TL;DR: In this article , the biological role and underlying mechanism of Wilms tumor 1-associated protein (WTAP) in OP and the differentiation of bone marrow mesenchymal stem cells (BMMSCs) were explored.
M2 macrophage-derived exosomal miR-486-5p influences the differentiation potential of bone marrow mesenchymal stem cells and osteoporosis
Jincheng Liu,Zhen-Hui Sun,Yu Cui You,Lu Zhang,De-Ren Hou,Guanghui Gu,Yun-Xia Chen,Guangjun Jiao +7 more
TL;DR: In vitro results demonstrated that M2 macrophage-derived exosomal miR-486-5p enhanced osteogenic capacity but inhibited the adipogenesis of BMMSCs, and pathway analysis showed that M1 macrophages-derivedExosomes stimulated osteogenic differentiation via the TGF-β/SMAD2 signalling pathway and osteoporosis.
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Long noncoding RNA KCNQ1OT1 inhibits osteoclast differentiation by regulating the miR-128-3p/NFAT5 axis
Hengshuo Zhang,Lu Chen,Ziyu Wang,Zhen-Hui Sun,Yu Shan,Xinghui Li,Linzeng Qi,Hongliang Wang,Yun-Xia Chen +8 more
TL;DR: It is found that the inhibition of osteoclast differentiation by KCNQ1OT1 overexpression could be rescued using a miR-128-3p mimic, while the enhancement of migration and osteoprotegerin differentiation by si-NFAT5 could be reversed with aMiR- 128- 3p inhibitor.