Zhen Chen
Regeneron
3 Papers
Zhen Chen is an academic researcher from Regeneron. The author has contributed to research in topics: Inflammation & Dupilumab. The author has an hindex of 2, co-authored 3 publications.
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Papers
Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults With Active Eosinophilic Esophagitis
Ikuo Hirano,Evan S. Dellon,Jennifer D. Hamilton,Margaret H. Collins,Kathryn A. Peterson,Mirna Chehade,Alain M. Schoepfer,Ekaterina Safroneeva,Marc E. Rothenberg,Gary W. Falk,Yehudith Assouline-Dayan,Qiong Zhao,Zhen Chen,Brian N. Swanson,Gianluca Pirozzi,Leda Mannent,Neil M.H. Graham,Bolanle Akinlade,Neil Stahl,George D. Yancopoulos,Allen Radin +20 more
TL;DR: In a phase 2 trial of patients with active EoE, dupilumab reduced dysphagia, histologic features of disease (including eosinophilic infiltration and a marker of type 2 inflammation), and abnormal endoscopic features, compared with placebo, and was generally well tolerated.
398
A basophil-neuronal axis promotes itch
Fang Wang,Fang Wang,Anna M. Trier,Fengxian Li,Fengxian Li,Seonyoung Kim,Zhen Chen,Jiani N. Chai,Madison R. Mack,Stephanie A. Morrison,Jennifer D. Hamilton,Jinok Baek,Jinok Baek,Ting-Lin B. Yang,Aaron M. Ver Heul,Amy Z. Xu,Zili Xie,Xintong Dong,Masato Kubo,Hongzhen Hu,Chyi Song Hsieh,Xinzhong Dong,Qin Liu,David J. Margolis,Marius Ardeleanu,Mark J. Miller,Brian S. Kim +26 more
TL;DR: In this paper, the authors identify that a large proportion of patients with atopic dermatitis harbor allergen-specific immunoglobulin E (IgE) and exhibit a propensity for acute itch flares.
169
A Basophil-Neuronal Axis Promotes Itch
Fang Wang,Anna M. Trier,Fengxian Li,Seonyoung Kim,Zhen Chen,Jiani N. Chai,Madison R. Mack,Stephanie A. Morrison,Jennifer D. Hamilton,Jinok Baek,Ting-Lin B. Yang,Aaron M. Ver Heul,Amy Z. Xu,Zili Xie,Xintong Dong,Masato Kubo,Hongzhen Hu,Chyi Song Hsieh,Xinzhong Dong,Qin Liu,David J. Margolis,Marius Ardeleanu,Mark J. Miller,Brian S. Kim +23 more
TL;DR: It is shown that a subpopulation of patients with atopic dermatitis exhibit a distinct pattern of acute itch flares, and a novel basophil-neuronal circuit that may underlie a variety of neuroimmune processes is highlighted.