Zhen Cao
Duke University
9 Papers
362 Citations
Zhen Cao is an academic researcher from Duke University. The author has contributed to research in topics: GABAB receptor & Receptor. The author has an hindex of 9, co-authored 9 publications. Previous affiliations of Zhen Cao include United States Department of Veterans Affairs.
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Papers
The Role of GABAB Receptor Activation in Absence Seizures of Lethargic (lh/lh) Mice
David A. Hosford,Suzanne Clark,Zhen Cao,Wilkie A. Wilson,Fu Hsiung Lin,Richard A. Morrisett,Alexandre Huin +6 more
TL;DR: Electrographic features and anticonvulsant sensitivity similar to those of human absence seizures in lethargic mice and enhanced GABAB receptor-mediated synaptic responses may underlie absence seizures, andGABAB receptor antagonists hold promise as anticonVulsants for absence seizures.
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Induction of c-fos mRNA by kindled seizures: complex relationship with neuronal burst firing
TL;DR: It is found that the occurrence of seizure-evoked synchronous action potentials during the seizure exhibited a perfect qualitative correlation with the presence of c-fos mRNA expression in the granule cells 30 min following the seizure (Fisher's exact test, p = 0.002).
235
Increased AMPA-sensitive quisqualate receptor binding and reduced NMDA receptor binding in epileptic human hippocampus
David A. Hosford,Barbara J. Crain,Zhen Cao,Douglas W. Bonhaus,Allan H. Friedman,Maxine M. Okazaki,J. V. Nadler,James O. McNamara +7 more
TL;DR: Contrary to expectations, ASQ receptor binding was significantly increased in the dentate gyrus stratum moleculare in patients with CPE, and it was unchanged in other hippocampal regions, suggesting that the increase in ASQ receptors binding may contribute to hyperexcitability in these epileptic patients.
144
Differences in the anatomic distribution of immediate-early gene expression in amygdala and angular bundle kindling development
David A. Hosford,Michele Simonato,Zhen Cao,N. Garcia-Cairasco,Jon M. Silver,Linda S. Butler,Cheolsu Shin,James O. McNamara +7 more
TL;DR: It is proposed that synaptic activation of glutamate receptors contributes to the expression of these diverse IEGs throughout the forebrain and provides a constellation of anatomic structures in which to investigate the structural and functional consequences of IEG expression.
61
Neural network of structures in which GABAB receptors regulate absence seizures in the lethargic (lh/lh) mouse model
TL;DR: This study found that anterior ventral lateral thalamic nucleus (VLa), nucleus reticularis thalami (NRT), nucleus reuniens (RE) passed all three screens, and hence are members of the neural network in which GABAB receptors regulate absence seizures in lh/lh mice.
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