Zhelun Yang
7 Papers
Zhelun Yang is an academic researcher. The author has contributed to research in topics: Medicine & Mesenchymal stem cell. The author has an hindex of 2, co-authored 4 publications.
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Papers
Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway.
Zhelun Yang,Zeyan Liang,Jian Rao,Haishu Xie,Maochao Zhou,Xiongjie Xu,Yike Lin,Fabin Lin,Chun-hua Wang,Chunmei Chen +9 more
TL;DR: H-EV exerts neuroprotective effects by delivering miR-21 to promote astrocyte transformation from the A1 phenotype to the A2 phenotype, providing new targets and ideas for the treatment of SCI.
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Comparing the Efficacy and Safety of Cell Transplantation for Spinal Cord Injury: A Systematic Review and Bayesian Network Meta-Analysis
TL;DR: Patients with SCI who receive transplantation of macrophages, MSCs, N SCs, or OECs may have improved disease prognosis and the number of adverse events associated with transplanted cells was low.
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Mesenchymal stem cell-derived extracellular vesicles therapy in traumatic central nervous system diseases: a systematic review and meta-analysis
TL;DR: In this paper , mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have recently proven to be a promising non-cellular therapy.
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Efficacy of extracellular vesicles of different cell origins in traumatic brain injury: A systematic review and network meta-analysis
TL;DR: In this article , a systematic review and network meta-analysis were conducted for two outcome indicators, modified Neurological Severity Score (mNSS) and Morris Water Maze (MWM), and they were ranked by the surface under the cumulative ranking curves (SUCRA). Bias risk assessment was performed with SYRCLE.
Small extracellular vesicles from hypoxia-preconditioned bone marrow mesenchymal stem cells attenuate spinal cord injury via miR-146a-5p-mediated regulation of macrophage polarization
Zeyan Liang,Zhelun Yang,Haishu Xie,Jian Rao,Xiongjie Xu,Yike Lin,Chun-hua Wang,Chunmei Chen +7 more
TL;DR: The data suggest that HSEVs attenuate spinal cord inflammation and injury in rats by transporting miR-146a-5p, which alters macrophage polarization, and provides new insights into the application of HSEVs as a therapeutic tool for spinal cord injury.
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