Safety assessment of GM plants: An updated review of the scientific literature.

We evaluated the chronic effects of Bt rice carrying the Cry1Ab protein (1.64 mg/kg) on offspring of highly inbred WZSP, fed with Bt rice for 360 days, in a 60-week feeding study. The WZSP offspring (n = 27) were assigned to two groups (Minghui86 group, female n = 6, male n = 5; Bt group, female n = 11, male n = 5). The average obtained Cry1Ab protein dosage for female and male pigs was 1.003 and 1.234 mg/kg body weight after 10 weeks of feeding, respectively. The experimental feed in the study was nutritionally matched in both groups. The average daily gain and feed conversion ratio of the females in week 3 and males from weeks 1 to 10 were different between the Bt and Minghui86 groups (P < 0.05), and the body weight of the male pigs in week 2 was greater in the Minghui86 group than that of the Bt group (P < 0.05). No other differences were observed, and there were no significant differences in the serum sex steroid level, hematology parameters, relative organ weights, or histopathology. Although differe...

Effects of 60-Week Feeding Diet Containing Bt Rice Expressing the Cry1Ab Protein on the Offspring of Inbred Wuzhishan Pigs Fed the Same Diet.

Rat feeding trials: A comprehensive assessment of contaminants in both genetically modified maize and resulting pellets.

Effects of long-term feeding with genetically modified Bt rice on the growth and reproductive performance in highly inbred Wuzhishan pigs

Genetically modified (GM) crops are being planted at large scale worldwide. In most of the countries, GM crops are processed into livestock feed. The land is used for cultivation of GM plants has been increased in recent years; in 2012 GM plants were grown on over 170 million hectares in 28 countries by 17.3 million farmers and extended to 185.1 million hectors in 2016 worldwide. GM plants have been used as feed for animals and the number of studies has proved their safety for animal and public health. This paper reviews the possible effects of GM crops on livestock, poultry, and aquatic animals by reviewing different type of studies, in which parameters such as performance, reproductive and health assessment were investigated. The most of peer-reviewed papers evaluating the effects of feeding animals with transgenic crops were based on GM plants with improved agronomic traits i.e. herbicide-tolerant plants and pets-tolerant plants; however, in some cases GM plants with boosted nutritional properties assessed. In most experiments, either Bt (Bacillus thuringiensis) maize, Roundup Ready (RR) soybean or both fed to animals. Measurable differences in various parameters were mostly observed in Bt maize and soybean fed separately or simultaneously to animals. In this review, scientific studies showing the effects of the use of GM products in the nutrition of domestic animals on performance, health and reproductive parameters are investigated.

http://www.agrifoodscience.org/index.php/TURJAF/article/download/2773/1322

Effects of Feeding Genetically Modified Crops to Domestic Animals: A Review

BACKGROUND
The objective of the present study was to investigate the chronic effect of transgenic maize lines by the insertion of the cry1Ac gene from Bacillus thuringiensis (Bt) on the growth performance, immune response and health using a Wuzhishan miniature pig model through a 196-day feeding study.

RESULTS
Based on the gender and weight, 72 Wuzhishan miniature pigs were randomly assigned one of the diets containing 65% non-transgenic isogenic corn or Bt corn at three stages of growth (day 0–69, 70–134 and 135–196). The potential toxicological effects of transgenic corn on pigs were explored. No difference between the diet treatments for growth performance and haematology parameters at any stages of growth. Although subtle differences in serum content of alanine aminotransferase, relative kidney weight and some immune response were observed between the Bt group and isogenic group, they were not considered as diet treatment-related.

CONCLUSION
Long-term feeding Bt corn carrying cry1Ac genes to Wuzhishan miniature pigs did not indicate adverse effects on the growth, immune response and health indicators at any stages of growth. © 2016 Society of Chemical Industry

Long-term toxicity study on genetically modified corn with cry1Ac gene in a Wuzhishan miniature pig model.

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Long-term toxicity study on genetically modified corn with cry1Ac gene in a Wuzhishan miniature pig model.