Zhaoxin Wen
Cornell University
10 Papers
6 Citations
Zhaoxin Wen is an academic researcher from Cornell University. The author has contributed to research in topics: Gene drive & CRISPR. The author has an hindex of 5, co-authored 6 publications.
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Papers
Computational and experimental performance of CRISPR homing gene drive strategies with multiplexed gRNAs
Samuel E. Champer,Suh Yeon Oh,Chen Liu,Zhaoxin Wen,Andrew G. Clark,Philipp W. Messer,Jackson Champer +6 more
TL;DR: It is found that homing drives have an optimal number of gRNAs, usually between two and eight, depending on the specific drive type and performance parameters, contradict the notion that resistance rates can be reduced to arbitrarily low levels by gRNA multiplexing.
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Molecular safeguarding of CRISPR gene drive experiments
Jackson Champer,Joan Chung,Yoo Lim Lee,Chen Liu,Emily Yang,Zhaoxin Wen,Andrew G. Clark,Philipp W. Messer +7 more
TL;DR: It is found that maternal deposition of both Cas9 and gRNA is required to form resistance alleles in the early embryo and that maternally-deposited Cas9 alone can power germline drive conversion in individuals that lack a genomic source of Cas9.
120
High-Resolution Determination of Kinetic Parameters of Sucrose Hydrolysis Based on Weak Measurement
TL;DR: In this article , a high-resolution scheme for determining the kinetic parameters of sucrose hydrolysis based on weak measurement is proposed, and the parameters including rate constant, half-life, activation energy and preexponential factor are experimentally determined.
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Theory of quantized photonic spin Hall effect in strained graphene under a sub-Tesla external magnetic field.
TL;DR: The quantized photonic spin Hall effect (PSHE) in the strained graphene-substrate system is predicted under a sub-Tesla external magnetic field, which is two orders of magnitude smaller than required to produce the quantized effect in the conventional graphene substrate system as mentioned in this paper .
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Multiple loci of small effect confer wide variability in efficiency and resistance rate of CRISPR gene drive
Jackson Champer,Zhaoxin Wen,Anisha Luthra,Riona Reeves,Joan Chung,Chen Liu,Yoo Lim Lee,Jingxian Liu,Emily Yang,Philipp W. Messer,Andrew G. Clark +10 more
TL;DR: To investigate the effects of natural genetic variation on resistance formation in Drosophila melanogaster, a CRISPR homing gene drive was developed and crossed into the genetically diverse Drosophile Genetic Reference Panel (DGRP) lines, measuring several performance parameters.
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