Zhao-xia Wang
7 Papers
2 Citations
Zhao-xia Wang is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Patient-derived micro-organospheres enable clinical precision oncology.
Sheng Ding,C. Hsu,Zhao-xia Wang,Naveen Natesh,R. E. Millen,Marcos Negrete,N Giroux,Grecia O. Rivera,Anders B. Dohlman,Shree Bose,Tomer Rotstein,Kassandra V. Spiller,Athena Yeung,Zhiguo Sun,Chongming Jiang,Rui Xi,Benjamin D. Wilkin,Peggy M. Randon,Ian O. Williamson,Daniel Nelson,Daniel Delubac,Sehwa Oh,Gabrielle Rupprecht,James Isaacs,Jing Jia,Chao-Hu Chen,John Paul Shen,Scott Kopetz,Shannon J. McCall,Amber Smith,Nikolce Gjorevski,Antje Walz,Scott J. Antonia,Estelle Marrer-Berger,Hans Clevers,David S. Hsu,Xiling Shen +36 more
TL;DR: In this paper , the authors used droplet emulsion microfluidics with temperature control and dead-volume minimization to rapidly generate thousands of micro-organospheres (MOSs) from low-volume patient tissues, which serve as an ideal patient-derived model for clinical precision oncology.
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Rapid tissue prototyping with micro-organospheres
Zhao-xia Wang,Matteo Boretto,R. E. Millen,Naveen Natesh,Elena S. Reckzeh,C. Hsu,Marcos Negrete,Haipei Yao,William Quayle,Brook E. Heaton,Alfred T. Harding,Shree Bose,Else Driehuis,Joep Beumer,Grecia O. Rivera,Ravian L. van Ineveld,Donald Gex,Jessica DeVilla,Daisong Wang,Jens Puschhof,Maarten H. Geurts,Athena Yeung,Cait E. Hamele,Amber Smith,Eric D. Bankaitis,Kun Xiang,Sheng Ding,Daniel Nelson,Daniel Delubac,Anne C. Rios,Ralph Abi-Hachem,David W. Jang,Bradley J. Goldstein,Carolyn M. Glass,Nicholas S. Heaton,David S. Hsu,Hans Clevers,Xiling Shen +37 more
TL;DR: Micro-organospheres (MOSs) as mentioned in this paper are droplet-encapsulated miniature three-dimensional (3D) tissue models that can be established rapidly from patient tissues or cells.
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Microorganospheres as a novel precision oncology platform in colorectal cancer.
C. Hsu,Zhao-xia Wang,Sehwa Oh,Gabrielle Rupprecht,Kelly J. Pittman,Amber Smith,Daniel Delubac,Xiling Shen,Jing Jia,S. David Hsu +9 more
TL;DR: The ability to generate MOS and perform a drug screen in < 14 days will allow for the development of a precision oncology platform that can be rapidly used in the clinic to guide therapy.
2
•Journal Article
Treatment Ideas and Methods for Treating Breast Cancer Guided by Molecular Classification
TL;DR: The gene types of breast cancer can be classified into three types according to its molecules: Luminal type A, luminal type B, HER-2-positive type, triple negative type.
1
Patient-derived skin MicroOrganoSpheres and clinical response to immunotherapy.
Rikhia Chakraborty,Katerina D. Fagan-Solis,Jessica DeVilla,Timothy Recaldin,Michael Bscheider,Nikolce Gjorevski,Aaron M. Fullerton,Rodney A. Prell,Zia Khan,Zhao-xia Wang,Shengli Ding,C.R. Glass,William R. Jeck,Shannon J. McCall,Georgia M. Beasley,Rajat Mohindra,S. David Hsu,Grace S. Chandler,Xiling Shen,Adrian Roth +19 more
TL;DR: In this paper , a microfluidic droplet technology that generates "mini" patient-derived organoids called MicroOrganoSpheres (MOS) was used to assess skin cell toxicity and cytokine release in response to ICI and targeted therapies.