The invention relates to the technical field of microorganisms, in particular relates to an anti-inflammatory effect of oxidative stress yeast metabolite and application of the oxidative stress yeast metabolite in preparation of anti-inflammatory products. The invention provides a preparation method of the oxidative stress yeast metabolite; an experiment shows that the yeast metabolite can inhibit expression of COX-2 and activation of an NF-kappaB signal channel and can play effects of inhibiting inflammatory cell infiltration, inhibiting increment of nuclear-cytoplasmic ratio of cells, and inhibiting epidermal keratinization and/or reducing swelling degree so as to prove that the yeast metabolite has an anti-inflammatory effect, can be applied to related fields of drugs, cosmetics, health care products, food and the like, and can be made into dosage forms such as tablets, capsules, cream and liquid.

Anti-inflammatory effect and application of oxidative stress yeast metabolite

The invention discloses a molecular marker for diagnosing cardiovascular diseases, and the molecular marker is Nlrp3. The invention further discloses purposes of the molecular marker in screening or preparing of reagents for diagnosing the cardiovascular diseases and purposes of the reagents in the preparation of kits for diagnosing the cardiovascular diseases. The mRNA expression level of Nlrp3 is significantly increased in the blood of patients with the cardiovascular diseases so that Nlrp3 can be used as a molecular indicator for cardiovascular disease detection, and has the advantages of being noninvasive, rapid, sensitive, high in specificity and the like.

Molecular marker Nlrp3 for diagnosing cardiovascular diseases and application thereof

The invention discloses an evaluation model for immunologic idiosyncrasy liver injuries. The evaluation model comprises an NLRP3 inflammasome and a component for promoting activation of the NLRP3 inflammasome, wherein the component for promoting activation of the NLRP3 inflammasome is Icarisid I. The invention further discloses a construction method of the evaluation model. The construction methodcomprises the steps of preparing an Icarisid I solution; preparing a mouse primary marrow macrophage, and adding LPS for performing stimulation; adding the prepared solution into the mouse primary marrow macrophage for stimulation; adding ATP for stimulation; performing Western blot detection on expression of a related protein of NLRP3 inflammasome, adopting ELISA for detecting the content of TNF-alpha and IL-1beta in a cell supernatant, determining the Caspase-1 activity, and performing statistical analysis.

Medicine idiosyncrasy liver injury model and construction method and application thereof

Application of NALP3-ASC inflammation complex and activator inhibitor thereof in terms of preparation of medicines for treating prion diseases

th , 2014; revised: Jul. 14 th , 2014; accepted: Jul. 23 rd , 2014 Abstract A case of sebaceous adenoma of the scapular skin of a huskies dog is described. Masses in scapular skin were found in a 10-year-old female huskies. Histopathological examination with H & E stain- ing showed multiple lobulated tumor cells separated by connective tissues. Majority of cells are sebocytes, and few reserve cells. The pathological feature of the case supported the diagnosis of sebaceous adenoma.

A Case of Canine Sebaceous Adenoma in Scapular Skin

The invention provides a standard plasmid and a kit for quantitative determination of an MST1 gene, also provides a primer for determining the MST1 gene, wherein the primer has the nucleotide sequencess shown in SEQ ID NO.2 and SED ID NO.3. By using the primer provided by the invention, appropriate real-time fluorescent quantitative PCR (polymerase chain reaction) system and conditions are found out, so as to achieve the quantitative determination of the MST1 gene. The determination method and the kit have the advantages of accurate determination, high sensitivity, favorable specificity, simpleness and convenience, and can greatly determinate the expression quantity of the MST1 gene in the mammal tissue or cell, so as to provide an effective tool for further studying the regulating and controlling effect of the MST1 gene in the mammal system.

Standard plasmid and kit for quantitative determination of MST1 gene

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Application of NALP3-ASC inflammation complex and activator inhibitor thereof in terms of preparation of medicines for treating prion diseases

A Case of Canine Sebaceous Adenoma in Scapular Skin

Standard plasmid and kit for quantitative determination of MST1 gene