Zhanlong He
Peking Union Medical College
15 Papers
26 Citations
Zhanlong He is an academic researcher from Peking Union Medical College. The author has contributed to research in topics: Immune system & Virus. The author has an hindex of 10, co-authored 15 publications.
Chat about Author
Papers
Comparative study of the immunogenicity in mice and monkeys of an inactivated CA16 vaccine made from a human diploid cell line
Erxia Yang,Chen Cheng,Ying Zhang,Jingjing Wang,Yanchun Che,Jing Pu,Chenghong Dong,Longding Liu,Zhanlong He,Shuaiyao Lu,Yuan Zhao,Li Jiang,Yun Liao,CongWen Shao,Qihan Li +14 more
TL;DR: Evidence is provided for the potential use of inactivated CA16 as a candidate for use in vaccines and the neutralizing antibody had a cross-neutralizing activity against different viral strains (genotype A and B).
33
Pathologic and immunologic characteristics of coxsackievirus A16 infection in rhesus macaques
Jingjing Wang,Ying Zhang,Xiaolong Zhang,Yajie Hu,Chenghong Dong,Longding Liu,Erxia Yang,Yanchun Che,Jing Pu,Xi Wang,Jie Song,Yun Liao,Min Feng,Yan Liang,Ting Zhao,Li Jiang,Zhanlong He,Shuaiyao Lu,Lichun Wang,Yanyan Li,Shengtao Fan,Lei Guo,Qihan Li +22 more
TL;DR: An immunologic analysis indicated a defective immune response, which included undetectable neutralizing antibodies and IFN-γ-specific memory T-cells in macaques infected with CV-A16, which may correlate with the immunological characteristics observed in the animals.
25
Generation of a Live Attenuated Influenza Vaccine that Elicits Broad Protection in Mice and Ferrets
Lulan Wang,Lulan Wang,Su-Yang Liu,Hsiang Wen Chen,Hsiang Wen Chen,Xu Juan,Maxime Chapon,Tao Zhang,Fan Zhou,Yao E. Wang,Natalie Quanquin,Guiqin Wang,Xiaoli Tian,Zhanlong He,Longding Liu,Wenhai Yu,David Jesse Sanchez,Yuying Liang,Taijiao Jiang,Robert L. Modlin,Barry R. Bloom,Qihan Li,Jane C. Deng,Paul Zhou,F. Xiao Feng Qin,Genhong Cheng,Genhong Cheng +26 more
TL;DR: These studies present an LAIV development strategy to rapidly generate and screen entire libraries of viral clones, and adoptive transfer of T cells from W7-791-immunized mice conferred heterologous protection, indicating a role for T cell-mediated immunity.
24
Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys
Jingjing Wang,Su-dong. Qi,Xiaolong Zhang,Ying Zhang,Longding Liu,Yanchun Che,Zhanlong He,Yuan Zhao,Shuaiyao Lu,Wenhai Yu,Qihan Li +10 more
TL;DR: The results showed that the specific immune response induced by the EV71 inactivated vaccine is effective against EV71 infection but is not affected by CA16 infection.
16
Global gene expression analysis of peripheral blood mononuclear cells in rhesus monkey infants with CA16 infection-induced HFMD.
Jie Song,Yajie Hu,Yunguang Hu,Jingjing Wang,Xiaolong Zhang,Lichun Wang,Lei Guo,Yancui Wang,Ruotong Ning,Yun Liao,Ying Zhang,Huiwen Zheng,Haijing Shi,Zhanlong He,Qihan Li,Longding Liu +15 more
TL;DR: The results revealed the gene expression profile of the immune system in response to CA16 in rhesus monkey infants and suggested that such an immune response was generated as a result of the positive mobilization of theimmune system.
12