The invention relates to a use of an miR-100 inhibitor in cancer metastasis reduction, and concretely relates to a use of a reagent for determining the miR-100 expression level in the preparation of breast cancer diagnosis reagents, and a use of the miR-100 inhibitor, and a use of the miR-100 inhibitor or an miR-100 antagonist in the preparation of medicines for treating breast cancer. Up-regulation of miR-100 in in-vivo tumor related macrophages and in-vitro induced M2 type macrophages is induced by tumor micro-environment. In in-vivo test, the microRNA antagonist knocks down the expression of the miR-100 in mouse mammary gland tumor tissues, and a case that in-situ tumor growth has no statistic difference, the quantity of lung metastasis tubercles is obviously down-regulated and the mammary gland tumor metastasis is inhibited in an experiment group of the miR-100 down-regulation in the tumor related macrophages is found.

Use of miR-100 inhibitor in cancer metastasis reduction

The invention discloses application of a miR-100 inhibitor in preparation of a medicine for treating a breast cancer. The miR-100 inhibitor is a miR-100 antisense nucleic acid chain, and the sequence is 5'-TTCGGATCTACGGGTT-3'. The miR-100 inhibitor disclosed by the invention can induce apoptosis of tumor cells, growth of tumors in tumor transplanted mice can be effectively induced, the sensitivity of breast cancer cells on chemotherapy medicines is increased, the effect of chemotherapy is improved, and the miR-100 is a latent new target for the medicine for treating the breast cancer, and is a new path for medical therapy.

Application of miR-100 inhibitor in preparation of medicine for treating breast cancer

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Application of miR-100 inhibitor in preparation of medicine for treating breast cancer