Antibacterial titanium surfaces for medical implants

A new antibacterial titanium-copper sintered alloy: preparation and antibacterial property.

Effect of Cu content on the antibacterial activity of titanium–copper sintered alloys

Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) are the most common infectious bacteria in our daily life, and seriously affect human’s health. Because of the frequent and extensive use of antibiotics, the microbial strains forming drug resistance have become more and more difficult to deal with. Herein, we utilized bovine serum albumin (BSA) as the template to synthesize uniform copper sulfide (CuS) nanoparticles via a biomineralization method. The as-prepared BSA-CuS nanocomposites showed good biocompatibility and strong near-infrared absorbance performance and can be used as an efficient photothermal conversion agent for pathogenic bacteria ablation with a 980 nm laser at a low power density of 1.59 W/cm2. The cytotoxicity of BSA-CuS nanocomposite was investigated using skin fibroblast cells and displayed good biocompatibility. Furthermore, the antibacterial tests indicated that BSA-CuS nanocomposite showed no antibacterial activity without NIR irradiation. In contrast, they demonstrat...

Strong Near-Infrared Absorbing and Biocompatible CuS Nanoparticles for Rapid and Efficient Photothermal Ablation of Gram-Positive and -Negative Bacteria

Asignificantnumberofhospital-acquiredinfectionsoccurduetoinefficientdisinfectionofhospitalsurfaces,instrumentsandroomsTheemergenceandwidespreadofmultiresistantformsofseveralmicroorganismshasledtoa situation where fewcompounds are able to inhibit or kill the infectious agents Several strategies to disinfect both clinical equipmentand theenvironmentareavailable,ofteninvolvingtheuseofantimicrobialchemicalsMorerecently, investigations into gas plasma, antimicrobial surfaces and vapour systems have gained interest as promising alternatives to conventional disinfectants This review provides updated information on the current and emergent disinfection strategies for clinical environments

/pdf/current-and-emergent-strategies-for-disinfection-of-hospital-2te98wp3nb.pdf

Current and emergent strategies for disinfection of hospital environments

Microstructure and mechanical properties of CrN films fabricated by high power pulsed magnetron discharge plasma immersion ion implantation and deposition

A novel plasma immersion ion implantation technique based on high power pulsed magnetron sputtering (HPPMS) discharge that can produce a high density metal plasma is described. The metal plasma is clean and does not suffer from contamination from macroparticles, and the process can be readily scaled up for industrial production. The hardware, working principle, and operation modes are described. A matching circuit is developed to modulate the high-voltage and HPPMS pulses to enable operation under different modes such as simultaneous implantation and deposition, pure implantation, and selective implantation. To demonstrate the efficacy of the system and technique, CrN films with a smooth and dense surface without macroparticles were produced. An excellent adhesion with a critical load of 59.9 N is achieved for the pure implantation mode.

Novel plasma immersion ion implantation and deposition hardware and technique based on high power pulsed magnetron discharge.

There is an increasing interest in reducing bacterial harmfulness in recent years. Copper-containing titanium nitride films were fabricated on commercial stainless steel using hybrid processes combining dual magnetron sputtering. The objective of this work is to obtain antibacterial surface properties through copper doping for consumer products such as household hardware. In the fabrication process, a titanium target was sputtered using a radio-frequency power supply for easy monitoring of the film color. Copper was also sputtered using a DC power supply. In order to optimize the surface properties, multi-layer films were deposited and the relative amount of copper in the films was modulated by the ratio of the deposition time of different targets. The deposited films exhibit superior corrosion resistance and the corrosion current of the treated sample is reduced to about one-sixth of that of the untreated one. The pin-on-disk results show that the treated samples possess low friction coefficients and the wear tracks are observed to be narrow and smooth. The copper-containing films are very effective in killing the bacteria Escherichia coli. A longer TiN deposition time may lead to a more superior antibacterial capability in addition to enhanced corrosion resistance and wear resistance.

Antibacterial copper-containing titanium nitride films produced by dual magnetron sputtering

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Microstructure and mechanical properties of CrN films fabricated by high power pulsed magnetron discharge plasma immersion ion implantation and deposition

Novel plasma immersion ion implantation and deposition hardware and technique based on high power pulsed magnetron discharge.

Antibacterial copper-containing titanium nitride films produced by dual magnetron sputtering