Zelpha D’Souza
Imperial College London
8 Papers
25 Citations
Zelpha D’Souza is an academic researcher from Imperial College London. The author has contributed to research in topics: Glomerulonephritis & Macrophage. The author has an hindex of 8, co-authored 8 publications. Previous affiliations of Zelpha D’Souza include Medical Research Council.
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Papers
De novo DNA methylation drives 5hmC accumulation in mouse zygotes
Rachel Amouroux,Buhe Nashun,Kenjiro Shirane,Shoma Nakagawa,Peter W. S. Hill,Zelpha D’Souza,Manabu Nakayama,Masashi Matsuda,Aleksandra Turp,Elodie Ndjetehe,Vesela Encheva,Nobuaki Kudo,Haruhiko Koseki,Hiroyuki Sasaki,Petra Hajkova +14 more
TL;DR: It is demonstrated using detailed immunofluorescence analysis and ultrasensitive LC-MS-based quantitative measurements that the initial loss of paternal 5mC does not require 5hmC formation, and an intricate interplay between DNA demethylation, de novo methylation and Tet3-driven hydroxylation is revealed.
Genetic Loci Modulate Macrophage Activity and Glomerular Damage in Experimental Glomerulonephritis
Jacques Behmoaras,Jennifer A. Smith,Zelpha D’Souza,Gurjeet Bhangal,Ratana Chawanasuntoropoj,Frederick W.K. Tam,Charles D. Pusey,Timothy J. Aitman,H. Terence Cook +8 more
TL;DR: Results demonstrate that a genetic influence on macrophage activation, rather than number, determines glomerular damage in immune-mediated glomerulonephritis.
AP-1 transcription factor JunD confers protection from accelerated nephrotoxic nephritis and control podocyte-specific Vegfa expression.
H. Terence Cook,Ruth M. Tarzi,Zelpha D’Souza,Gaëlle Laurent,Wei-Chou Lin,Timothy J. Aitman,Fatima Mechta-Grigoriou,Jacques Behmoaras +7 more
TL;DR: It is suggested that deficiency of Jund may cause increased oxidative stress in podocytes, leading to altered VEGFA expression and subsequent glomerular injury in Crgn, and small-interfering RNA–mediated JUND knockdown in conditionally immortalized human podocyte cell lines led to increased HIF1A expression.
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Experimental crescentic glomerulonephritis: a new bicongenic rat model
Zelpha D’Souza,Stephen P. McAdoo,Jennifer A. Smith,Charles D. Pusey,H. Terence Cook,Jacques Behmoaras,Timothy J. Aitman +6 more
TL;DR: This is the first time that CRGN has been induced on a normally resistant rat genetic background and identifies the LEW.WCrgn1,2 strain as a new, potentially valuable model of macrophage-dependent glomerulonephritis.
Characterization of the macrophage transcriptome in glomerulonephritis-susceptible and -resistant rat strains
Klio Maratou,Jacques Behmoaras,Chris Fewings,Prashant K. Srivastava,Zelpha D’Souza,Jennifer A. Smith,Laurence Game,Terence Cook,Timothy J. Aitman +8 more
TL;DR: The results identify distinct macrophage transcriptome profiles between two rat strains that differ in susceptibility to glomerulonephritis, provide novel positional candidates for Crgn3–7 and define groups of genes that play a significant role in differential regulation of macrophages activity.
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