Zehui Lei
Chinese Academy of Sciences
5 Papers
3 Citations
Zehui Lei is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Ubiquitin ligase & Ubiquitin. The author has an hindex of 2, co-authored 5 publications.
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Papers
M. tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival
Pupu Ge,Zehui Lei,Yang Yu,Zhe Lu,Lihua Qiang,Qiyao Chai,Yong Zhang,Dongdong Zhao,Bingxi Li,Yu Pang,Cui Hua Liu,Jing Wang +11 more
TL;DR: In this paper, the eukaryotic-type protein kinase G (PknG) prevented the activation of AKT via competitively binding to its pleckstrin homology (PH) domain, leading to autophagy induction.
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Mycobacterium tuberculosis protein kinase G acts as an unusual ubiquitinating enzyme to impair host immunity.
Jing Wang,Pupu Ge,Zehui Lei,Zhe Lu,Lihua Qiang,Qiyao Chai,Yong Zhang,Dongdong Zhao,Bingxi Li,Jiaqi Su,Ruchao Peng,Yu Pang,Yi Shi,Yu Zhang,George F. Gao,Xiao-Bo Qiu,Cui Hua Liu +16 more
TL;DR: In this article, the authors demonstrate that protein kinase G (PknG), a eukaryotic-type serine-threonine (STPK), is secreted into host macrophages to promote intracellular survival of the pathogen.
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Ubiquitination-Dependent Regulation of Small GTPases in Membrane Trafficking: From Cell Biology to Human Diseases
TL;DR: In this article, the authors introduce small GTPases-mediated membrane trafficking pathways and the biological processes of ubiquitination-dependent regulation of small gTPases, including the regulation of GTPase stability, activity and localization.
A Mycobacterium tuberculosis effector protein attacks host innate immunity by acting as an unusual ubiquitinating enzyme
Jin-Yun Wang,Pupu Ge,Zehui Lei,Zhe Lu,Lihua Qiang,Qiyao Chai,Zhang Y,Dongdong Zhao,Bufan Li,Jiaqi Su,Ruchao Peng,Yu Pang,Yulong Shi,Ge Gao,Xiao-Bo Qiu,Chunye Liu +15 more
TL;DR: It is demonstrated that Mtb PknG promotes ubiquitination of the key components of the host innate immunity by acting as an unusual ubiquitinating enzyme to suppress innate immunity.
Simulated microgravity suppresses MAPK pathway-mediated innate immune response to bacterial infection and induces gut microbiota dysbiosis
Jing Wang,Conghui Han,Zhe Lu,Pupu Ge,Yu Cui,Dongdong Zhao,Xi Yang,Bo Wu,Lihua Qiang,Yong Zhang,Qiyao Chai,Zehui Lei,Ling Li,Cui Hua Liu,Lingqiang Zhang +14 more
TL;DR: RNA‐sequencing analysis provides new insights into microgravity‐mediated innate immune suppression and intestinal microbiota disturbance, and suggests that probiotic VSL#3 has great potential as a dietary supplement in protecting individuals from spaceflight mission‐associated infections and gut microbiota dysbiosis.