Zebin Hong
Chinese Academy of Sciences
6 Papers
18 Citations
Zebin Hong is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Plasminogen activator & Plasminogen activator inhibitor-1. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Zebin Hong include Aarhus University.
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Papers
PCSK9 Inhibition: From Current Advances to Evolving Future
Chunping Liu,Jingtan Chen,Huiqi Chen,Tong Zhang,Dongyue He,Qiyuan Luo,Jiaxin Chi,Zebin Hong,Yi Jen Liao,Shihui Zhang,Qizhe Wu,Huan Cen,Guangzhong Chen,Jinxin Li,Lei Wang +14 more
TL;DR: This review systematically summarized the application, preclinical studies, safety, mechanism of action, and latest research progress of PCSK9 inhibitors, aiming to provide ideas for the drug research and development and the clinical application ofPCSK9 in cardiovascular diseases and expand its application in other diseases.
Structural Insight into Inactivation of Plasminogen Activator Inhibitor-1 by a Small-Molecule Antagonist
Zhonghui Lin,Jan K. Jensen,Zebin Hong,Zebin Hong,Xiaoli Shi,Xiaoli Shi,Lihong Hu,Peter A. Andreasen,Mingdong Huang,Mingdong Huang +9 more
TL;DR: X-ray crystal structure analysis of PAI-1 in complex with a small-molecule antagonist, embelin, provides structural clues to an understanding of PAi- 1 inactivation by small- molecule antagonists and an important step toward the design of drugs targeting PAI -1.
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A specific plasminogen activator inhibitor‐1 antagonist derived from inactivated urokinase
Lihu Gong,Valérie Proulle,Chao Fang,Zebin Hong,Zhonghui Lin,Min Liu,Guangpu Xue,Cai Yuan,Lin Lin,Barbara C. Furie,Robert Flaumenhaft,Peter A. Andreasen,Bruce Furie,Mingdong Huang,Mingdong Huang +14 more
TL;DR: In vivo, using a laser‐induced thrombosis mouse model in which thrombus formation and fibrinolysis are monitored by intravital microscopy, PAItrap reduced fibrin generation and inhibited platelet accumulation following vascular injury, demonstrating the feasibility to generate PAI‐1 inhibitors using inactivated urokinase.
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Design, synthesis, and SAR of embelin analogues as the inhibitors of PAI-1 (plasminogen activator inhibitor-1).
TL;DR: Based on the structure of embelin, a series of analogues were designed, synthesized, and evaluated for their ability to inhibit PAI-1, finding that the inhibitory potency largely depended on the hydroxyl groups at C2 and C5, and the length of the alkyl chains at C3 and C6.
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Patent
Recombinant PAI-1 inhibitor, composition containing recombinant PAI-1 inhibitor, and uses of recombinant PAI-1 inhibitor and composition in treatment and detection
Mingdong Huang,Lin Zhonghui,Lihu Gong,Zebin Hong,Cai Yuan,Jiang Longguang,Liu Min +6 more
- 22 Jul 2015
TL;DR: In this paper, a recombinant PAI-1 inhibitor was proposed, which is an uPA hydrolase domain with S195A mutation or a PAI 1 hydrolases domain with s195A mutations, and has PAI1 binding force.
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