ZE Barter
Simcyp
18 Papers
126 Citations
ZE Barter is an academic researcher from Simcyp. The author has contributed to research in topics: Population & Physiologically based pharmacokinetic modelling. The author has an hindex of 13, co-authored 18 publications. Previous affiliations of ZE Barter include University of Sheffield & Royal Hallamshire Hospital.
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Papers
Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver.
ZE Barter,Martin K Bayliss,Philip H Beaune,Alan R. Boobis,David J. Carlile,Robert Edwards,J. Brian Houston,Brian G. Lake,John C. Lipscomb,Olavi Pelkonen,Geoffrey T. Tucker,Amin Rostami-Hodjegan +11 more
TL;DR: The findings indicate the importance of considering differences between study populations when forecasting in vivo pharmacokinetic behaviour and recommend that the estimates (and their variances) from the current meta-analysis be used when predicting in vivo kinetic parameters from in vitro data.
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A Mechanistic Framework for In Vitro–In Vivo Extrapolation of Liver Membrane Transporters: Prediction of Drug–Drug Interaction Between Rosuvastatin and Cyclosporine
Masoud Jamei,F. Bajot,F. Bajot,Sibylle Neuhoff,ZE Barter,Jiansong Yang,Amin Rostami-Hodjegan,Amin Rostami-Hodjegan,K Rowland-Yeo +8 more
TL;DR: An in vitro–in vivo extrapolation (IVIVE)-linked mechanistic physiologically based pharmacokinetic (PBPK) framework for modelling liver transporters and their interplay with liver metabolising enzymes has been developed and implemented within the Simcyp Simulator®.
Covariation of Human Microsomal Protein Per Gram of Liver with Age: Absence of Influence of Operator and Sample Storage May Justify Interlaboratory Data Pooling
ZE Barter,Joanna Chowdry,Jacqueline R Harlow,John E. Snawder,John C. Lipscomb,Amin Rostami-Hodjegan +5 more
TL;DR: Investigation of the relationship between age and MPPGL provided preliminary evidence thatMPPGL values increase from birth to a maximum of 40 mg g-1 at approximately 28 years followed by a gradual decrease in older age, and appropriate age-adjusted scaling factors should be used in extrapolating in vitro clearance values to clinical studies.
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Differences in Cytochrome P450-Mediated Pharmacokinetics Between Chinese and Caucasian Populations Predicted by Mechanistic Physiologically Based Pharmacokinetic Modelling
TL;DR: The results of this study indicate the value of simulation based on mechanistic physiologically based pharmacokinetic modelling (PBPK) in anticipating the likely extent of any differences in the kinetics of CYP substrates in Chinese and Caucasian populations arising from demographic, physiological and genetic differences.
121
Application of permeability‐limited physiologically‐based pharmacokinetic models: Part I–digoxin pharmacokinetics incorporating P‐glycoprotein‐mediated efflux
Sibylle Neuhoff,Karen Rowland Yeo,ZE Barter,Masoud Jamei,David B. Turner,Amin Rostami-Hodjegan,Amin Rostami-Hodjegan +6 more
TL;DR: In this article, the authors used the Simcyp Simulator to predict the magnitude of P-glycoprotein (P-gp)-mediated drug-drug interactions between digoxin and P-gp inhibitors.
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