Zbyszek Otwinowski
University of Texas Southwestern Medical Center
127 Papers
575 Citations
Zbyszek Otwinowski is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Biology & Protein structure. The author has an hindex of 43, co-authored 115 publications. Previous affiliations of Zbyszek Otwinowski include University of Illinois at Chicago & University of Texas at Dallas.
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Papers
Crystallographic Determination of the Active Site Iron and Its Ligands in Soybean Lipoxygenase L-1
TL;DR: Five ligands of the active site iron atom in soybean lipoxygenase L-1 have been identified from the electron density map of the crystallized enzyme, confirming the previous view that these three histidines are essential for activity and binding of iron.
141
A tethered delivery mechanism explains the catalytic action of a microtubule polymerase.
Pelin Ayaz,Sarah Munyoki,Elisabeth A. Geyer,Felipe-Andres Piedra,Emily S. Vu,Raquel Bromberg,Zbyszek Otwinowski,Nick V. Grishin,Chad A. Brautigam,Luke M. Rice +9 more
TL;DR: The structure of the TOG2 domain from Stu2p bound to yeast αβ-tubulin is reported, which can explain catalyst-like behavior and also predicts that the polymerase action changes the configuration of the microtubule end.
The 2.4 Å Crystal Structure of Cholera Toxin B Subunit Pentamer: Choleragenoid
R. Zhang,Mary L. Westbrook,Edwin M. Westbrook,Edwin M. Westbrook,David Scott,Zbyszek Otwinowski,P R Maulik,Robert A. Reed,G. Graham Shipley,G. Graham Shipley +9 more
TL;DR: The structure of the B subunits, and their pentameric arrangement, closely resembles that reported for the intact holotoxin, choleragen, the heat-labile enterotoxin from Escherichia coli, and for a Choleragenoid-GM1 pentasaccharide complex.
124
Structural basis for Marburg virus VP35-mediated immune evasion mechanisms.
Parameshwaran Ramanan,Megan R. Edwards,Reed S. Shabman,Daisy W. Leung,Ariel C. Endlich-Frazier,Dominika Borek,Zbyszek Otwinowski,Gai Liu,Juyoung Huh,Christopher F. Basler,Gaya K. Amarasinghe +10 more
TL;DR: Insights on differential PAMP recognition and inhibition of IFN induction by a similar filoviral VP35 fold are revealed, revealing the structural and functional plasticity of a highly conserved virulence factor.
114
High-resolution timing of cell cycle-regulated gene expression
TL;DR: These results reveal distinct subphases of the cell cycle undetectable by morphological observation, as well as the precise timeline of macromolecular complex assembly during key cell cycle events.
91