Zachary Niday
Harvard University
6 Papers
3 Citations
Zachary Niday is an academic researcher from Harvard University. The author has contributed to research in topics: Voltage-dependent calcium channel & Epilepsy. The author has an hindex of 4, co-authored 6 publications. Previous affiliations of Zachary Niday include University of Connecticut.
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Papers
Potassium channel gain of function in epilepsy: an unresolved paradox
TL;DR: The current state of the field regarding the gain-of-function potassium channel variants associated with epilepsy are described and the possible cellular mechanisms behind the development of seizures and epilepsy in these patients are speculated on.
Epilepsy-Associated KCNQ2 Channels Regulate Multiple Intrinsic Properties of Layer 2/3 Pyramidal Neurons.
TL;DR: It is found that conditional ablation of Kcnq2 from mouse neocortex leads to hyperexcitability of layer 2/3 (L2/3) pyramidal neurons, exhibiting an increased input resistance and action potential frequency, as well as a reduced medium afterhyperpolarization (mAHP), a conductance partly mediated by KCNQ2 channels.
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Cortical KCNQ2/3 channels; insights from knockout mice.
TL;DR: The essential role for KCNQ2 in controlling neuronal excitability is demonstrated by showing that deletion of Kcnq2—but not KCNq3—from cortical pyramidal neurons is sufficient for the development of aberrant EEG activity and leads to death by the third week of life.
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Inhibition of KCNQ2/3 channels by HN38 and XE991 depends on the conformation of the outer vestibule.
Elizabeth Rodier,Zachary Niday,Klarita Doci,Lei Wang,Fajun Nan,Zhaobing Gao,Anastasios V. Tzingounis +6 more
TL;DR: It is concluded that the KCNQ3 outer vestibule conformation regulates the ability of blockers, like HN38 as well as XE991, to inhibit KCNNQ2/3 channels, which should be considered for the design of newKCNQ1-5 auxiliary neuronal subunit beta-secretase 1 compounds.
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The Role of CaV2.1 Channel Facilitation in Synaptic Facilitation.
Christopher Weyrer,Josef Turecek,Zachary Niday,Pin W. Liu,Evanthia Nanou,William A. Catterall,Bruce P. Bean,Wade G. Regehr +7 more
TL;DR: It is found that, under conditions of physiological calcium and near-physiological temperatures, synaptic facilitation at hippocampal CA3 to CA1 synapses was not attenuated in Ca IM-AA mice and facilitation was paradoxically more prominent at two cerebellar synapses.