Zachary Grimes
Icahn School of Medicine at Mount Sinai
15 Papers
1 Citations
Zachary Grimes is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 6, co-authored 11 publications.
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Papers
Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).
Alberto Paniz-Mondolfi,Clare Bryce,Zachary Grimes,Ronald E. Gordon,Jason Reidy,John A. Lednicky,Emilia Mia Sordillo,Mary Fowkes +7 more
TL;DR: Observations of virus in neural tissue, in conjunction with clinical correlates of worsening neurologic symptoms, pave the way to a closer understanding of the pathogenic mechanisms underlying central nervous system involvement by SARS‐CoV‐2.
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Pathophysiology of SARS-CoV-2: the Mount Sinai COVID-19 autopsy experience.
Clare Bryce,Zachary Grimes,Elisabet Pujadas,Sadhna Ahuja,Mary Beth Beasley,Randy A. Albrecht,Tahyna Hernandez,Aryeh Stock,Zhen Zhao,Mohamed Rizwan AlRasheed,Joyce Chen,Li Li,Diane Wang,Adriana D. Corben,G. Kenneth Haines,William H. Westra,Melissa Umphlett,Ronald E. Gordon,Jason Reidy,Bruce Petersen,Fadi Salem,Maria Isabel Fiel,Siraj M. El Jamal,Nadejda M. Tsankova,Jane Houldsworth,Zarmeen Mussa,Brandon Veremis,Emilia Mia Sordillo,Melissa R. Gitman,Michael D. Nowak,Rachel Brody,Noam Harpaz,Miriam Merad,Sacha Gnjatic,Wen-Chun Liu,Michael Schotsaert,Lisa Miorin,Teresa A. Aydillo Gomez,Irene Ramos-Lopez,Adolfo García-Sastre,Ryan Donnelly,Patricia Seigler,Calvin Keys,Jennifer Cameron,Isaiah Moultrie,Kae Lynn Washington,Jacquelyn D. Treatman,Robert Sebra,Jeffrey S. Jhang,Adolfo Firpo,John A. Lednicky,Alberto Paniz-Mondolfi,Carlos Cordon-Cardo,Mary Fowkes +53 more
TL;DR: The first 100 COVID-19-positive autopsies performed at the Mount Sinai Hospital in New York City revealed large pulmonary emboli in six cases and diffuse alveolar damage was present in over 90% of cases as mentioned in this paper.
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COVID-19–Associated cardiac pathology at the postmortem evaluation: a collaborative systematic review
Raghed Almamlouk,Tarek Kashour,Sawsan Obeidat,Melanie C. Bois,Joseph J. Maleszewski,Osama Omrani,Rana Tleyjeh,Elie F. Berbari,Zaher Chakhachiro,Bassel Zein-Sabatto,Dana Gerberi,Imad M. Tleyjeh,Alberto E. Paniz Mondolfi,Aloke V. Finn,Amaro Nunes Duarte-Neto,Amy Rapkiewicz,Andrea Frustaci,Arthur-Atilla Keresztesi,Brian Hanley,Bruno Märkl,Christelle Lardi,Clare Bryce,Diana Lindner,Diego Aguiar,Dirk Westermann,Edana Stroberg,Eric J. Duval,Esther Youd,Gaetano Bulfamante,Isabelle Salmon,Johann Auer,Klaus Hirschbühl,Lara Absil,Lisa M. Barton,Luiz Fernando Ferraz da Silva,Luiza Moore,Marisa Dolhnikoff,Martin Lammens,Michael Osborn,Myriam Remmelink,Paulo Hilário Nascimento Saldiva,Philippe G. Jorens,Randall D. Craver,Renata Aparecida de Almeida Monteiro,Roberto Scendoni,Sanjay Mukhopadhyay,Tadaki Suzuki,Thais Mauad,Tony Fracasso,Zachary Grimes +49 more
TL;DR: The authors in this paper performed a systematic review to better understand the various aspects of the cardiovascular complications of COVID-19 by pooling data from a large number of autopsy studies.
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Broad Severe Acute Respiratory Syndrome Coronavirus 2 Cell Tropism and Immunopathology in Lung Tissues From Fatal Coronavirus Disease 2019.
Suzane Ramos da Silva,Enguo Ju,Wen Meng,Alberto E. Paniz Mondolfi,Sanja Dacic,Anthony Green,Clare Bryce,Zachary Grimes,Mary Fowkes,Emilia Mia Sordillo,Carlos Cordon-Cardo,Haitao Guo,Shou-Jiang Gao +12 more
TL;DR: In this paper, the authors performed multicolor staining for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteins and lineage markers to define viral tropism and lung pathobiology in 5 autopsy cases.
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Broad SARS-CoV-2 cell tropism and immunopathology in lung tissues from fatal COVID-19
Suzane Ramos da Silva,Enguo Ju,Wen Meng,Alberto E. Paniz Mondolfi,Sanja Dacic,Anthony Green,Clare Bryce,Zachary Grimes,Mary Fowkes,Emilia Mia Sordillo,Carlos Cordon-Cardo,Haitao Guo,Shou-Jiang Gao +12 more
TL;DR: In lung tissues from severely affected COVID-19 patients, there is evidence for broad SARS-CoV-2 cell tropisms, activation of immune cells, and clearance of immunosuppressive cells, which could contribute to severe tissue damage, thromboemboli, excess inflammation and compromised adaptive immune responses.