Z. Yan
6 Papers
Z. Yan is an academic researcher. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications.
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Papers
HSP27 Attenuates cGAS-Mediated IFN-β Signaling through Ubiquitination of cGAS and Promotes PRV Infection
Xiangrong Li,Jingying Xie,Di Li,Hongshan Li,Yuhui Niu,B. Wu,Yanmei Yang,Z. Yan,Xiangbo Zhang,Lei Chen,Ruofei Feng +10 more
TL;DR: It is revealed for the first time that HSP27 is a novel negative regulator of the cGAS-STING signaling pathway induced by PRV infection or poly(dA:dT) activation and demonstrate that H SP27 plays a crucial role inPRV infection.
IFITM2 Presents Antiviral Response through Enhancing Type I IFN Signaling Pathway
Lei Chen,Xiangrong Li,Yingying Deng,Yingjie Bi,Z. Yan,Yanmei Yang,Xiangbo Zhang,Huixia Li,Jingying Xie,Ruofei Feng +9 more
TL;DR: In this paper , the authors reported that IFITM can significantly inhibit EMCV infectivity in HEK293 cells and that the N-terminal domain plays an active role in the antiviral activity and the activation of IFN-β by the human interferon-inducible transmembrane proteins.
Mammalian orthoreovirus capsid protein σ3 antagonizes RLR-mediated antiviral responses by degrading MAVS.
Dianyu Li,Rong Mo,Xiaoyi Li,Rongrong Cheng,Jingying Xie,Hongshan Li,Yanmei Yang,Shasha Li,Huixia Li,Z. Yan,Suocheng Wei,Adi Idris,Xiangrong Li,Ruofei Feng +13 more
TL;DR: MRV σ3 protein inhibits RLR-mediated antiviral responses by degrading MAVS and inhibiting the expression of RIG-I and melanoma differentiation-associated gene 5.
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Pseudorabies virus UL38 attenuates the cGAS-STING signaling pathway by recruiting Tollip to promote STING for autophagy degradation
Z. Yan,Jingying Xie,Zhengyang Hou,Yaxin Zhang,Jiayu Yue,Xiangbo Zhang,Lei Chen,Yanmei Yang,Xiangrong Li,Huixia Li,Ruofei Feng +10 more
TL;DR: Pseudorabies virus UL38 protein suppresses the cGAS-STING signaling pathway by recruiting Tollip, promoting STING degradation via autophagy, thereby attenuating IFN-β production and facilitating viral persistence in the host through innate immunity evasion mechanisms.
Pseudorabies Virus ICP0 Abolishes Tumor Necrosis Factor Alpha-Induced NF-κB Activation by Degrading P65
TL;DR: PRV protein ICP0 is shown for the first time to enable escape from innate immune response through the regulation of NF-κB during PRV infection.