11 Papers
63 Citations
Z. Chen is an academic researcher from University of Texas MD Anderson Cancer Center. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 7, co-authored 11 publications. Previous affiliations of Z. Chen include Fudan University.
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Papers
Diagnostic Testing for IDH1 and IDH2 Variants in Acute Myeloid Leukemia: An Algorithmic Approach Using High-Resolution Melting Curve Analysis
Keyur P. Patel,Bedia A. Barkoh,Z. Chen,Deqin Ma,Neelima Reddy,L. Jeffrey Medeiros,Rajyalakshmi Luthra +6 more
TL;DR: Clinical assays using high-resolution melting (HRM) analysis to screen for all four variants listed above, followed by Sanger sequencing confirmation are developed, showing near-perfect concordance for all positive and negative results for IDH1 and IDH2.
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Acute myeloid leukemia (AML) with erythroid predominance exhibits clinical and molecular characteristics that differ from other types of AML.
Zhuang Zuo,L. Jeffrey Medeiros,Z. Chen,Dingsheng Liu,Carlos E. Bueso-Ramos,Rajyalakshmi Luthra,Sa A. Wang +6 more
TL;DR: The clinical, cytogenetic, and molecular features of AML with erythroid predominance in the non-therapy-related setting are much closer to those of a high-grade myelodysplastic syndrome than they are to other types of AMl.
Clinical significance of trisomy 8 that emerges during therapy in chronic myeloid leukemia
Wei Wang,Z. Chen,Zhihong Hu,Cheng Cameron Yin,Shaoying Li,S Bai,Carlos E. Bueso-Ramos,L. J. Medeiros,Shimin Hu +8 more
TL;DR: The interval from initial diagnosis of CML to emergence of ACAs may also be important as the same ACA can have differential impact on tyrosine kinase inhibitor (TKI) treatment and prognosis when it emerges at the time of initial CML diagnosis versus during therapy.
Differential clinical and prognostic impact of myeloid sarcoma vs medullary myeloid blast phase of chronic myelogenous leukemia in the era of tyrosine kinase inhibitor therapy
Z. Chen,Z. Chen,Wei Lien Wang,Jorge E. Cortes,E. Liu,Roberto N. Miranda,Chen Zhao,Ji Yuan,Xinyan Lu,Wei Yang,M. D. Ameri,Hagop M. Kantarjian,L. J. Medeiros,Shimin Hu +13 more
TL;DR: Myeloid sarcoma is a rare neoplasm consisting of immature myeloid cells that forms a tumor mass at an anatomic site other than the bone marrow (BM) that develops in patients with chronic myelogenous leukemia (CML).
Somatic Deletions of the PolyA Tract in the 3′ Untranslated Region of Epidermal Growth Factor Receptor Are Common in Microsatellite Instability–High Endometrial and Colorectal Carcinomas
Deqin Ma,Z. Chen,Christopher Nero,Keyur P. Patel,Emad M. Daoud,Hanyin Cheng,Bojana Djordjevic,Russell Broaddus,L. Jeffrey Medeiros,Asif Rashid,Rajyalakshmi Luthra +10 more
TL;DR: Deletions of EGFR 3' UTR polyA tract are frequent in endometrial and colorectal carcinomas, are confined almost exclusively to MSI-H tumors, and do not affect KRAS and BRAF mutations.