Yusuke Oka
Taisho Pharmaceutical Co.
6 Papers
65 Citations
Yusuke Oka is an academic researcher from Taisho Pharmaceutical Co.. The author has contributed to research in topics: Chemistry & Hydroxamic acid. The author has an hindex of 5, co-authored 5 publications.
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Papers
Patent
Novel hydroxamic acid derivative
Hajime Takashima,Risa Tsuruta,Tetsuya Yabuuchi,Yusuke Oka,Hiroki Urabe,Yoichiro Suga,Masato Takahashi,Fumito Uneuchi,Hironori Kotsubo,Muneo Shoji,Yasuko Kawaguchi +10 more
- 20 Apr 2011
TL;DR: In this article, a novel compound which is useful as a pharmaceutical composition by inhibiting an LpxC activity, thereby exhibiting potent antimicrobial activity against gram-negative bacteria including Pseudomonas aeruginosa and its drug resistant bacteria.
37
Discovery and optimization of a series of 2-aminothiazole-oxazoles as potent phosphoinositide 3-kinase γ inhibitors
Yusuke Oka,Tetsuya Yabuuchi,Yasuyuki Fujii,Hidenori Ohtake,Shunichi Wakahara,Kayo Matsumoto,Mayumi Endo,Yunoshin Tamura,Yoshinori Sekiguchi +8 more
TL;DR: A novel series of 2-aminothiazole-oxazoles was designed and synthesized as part of efforts to develop potent phosphoinositide 3-kinase γ (PI3Kγ) inhibitors and resulted in the identification of compounds 10 and 15, which displayed potent inhibitory activities in enzyme-based and cell-based assays.
27
Discovery of N-{5-[3-(3-hydroxypiperidin-1-yl)-1,2,4-oxadiazol-5-yl]-4-methyl-1,3-thiazol-2-yl}acetamide (TASP0415914) as an orally potent phosphoinositide 3-kinase γ inhibitor for the treatment of inflammatory diseases.
Yusuke Oka,Tetsuya Yabuuchi,Takahiro Oi,Kuroda Shoichi,Yasuyuki Fujii,Hidenori Ohtake,Tomoyuki Inoue,Shunichi Wakahara,Kayo Kimura,Kiyoko Fujita,Mayumi Endo,Kyoko Taguchi,Yoshinori Sekiguchi +12 more
TL;DR: The synthesis and the structure-activity relationships (SAR) of a series of 2-amino-5-oxadiazolyl thiazoles are described, culminating in the identification of 8j (TASP0415914), an orally potent inhibitor of phosphoinositide 3-kinase γ (PI3Kγ).
25
Ring-fused pyrazole derivatives as potent inhibitors of lymphocyte-specific kinase (Lck): Structure, synthesis, and SAR.
Tetsuo Takayama,Hiroki Umemiya,Hideaki Amada,Tetsuya Yabuuchi,Takeshi Koami,Fumiyasu Shiozawa,Yusuke Oka,Akiko Takaoka,Akie Yamaguchi,Mayumi Endo,Masakazu Sato +10 more
TL;DR: A novel series of ring-fused pyrazole derivatives as lymphocyte-specific kinase (Lck) inhibitors were identified and exhibited good enzyme inhibitory activity as well as excellent cellular activity against mixed lymphocyte reaction (MLR).
19
Patent
Hydroxamic acid derivative
Hajime Takashima,Risa Tsuruta,Tetsuya Yabuuchi,Yusuke Oka,Hiroki Urabe,Yoichiro Suga,Masato Takahashi,Fumito Uneuchi,Hironori Kotsubo,Muneo Shoji,Yasuko Kawaguchi +10 more
- 20 Apr 2011
TL;DR: In this article, the problem of providing a novel compound which is useful as a pharmaceutical product, and which has high antibacterial activity with regard to gram-negative bacteria such as pseudomonas aeruginosa and with regards to the drug-resistant bacteria of gram negative bacteria.
5