Yusuke Oka
University of Tokyo
9 Papers
50 Citations
Yusuke Oka is an academic researcher from University of Tokyo. The author has contributed to research in topics: Acyl group & Transmetalation. The author has an hindex of 4, co-authored 9 publications.
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Papers
Palladium-catalyzed reaction of acylzirconocene chloride and stereoselective formation of bicyclo[3.3.0] compounds.
TL;DR: The acylzirconocene chloride complex as an acyl group donor reacts with omega-unsaturated alpha,beta-enones and -ynones under Pd-Me( 2)Zn(Me(2)AlCl)-catalyzed conditions to give stereoselectively bicyclo[3.3.0] compounds.
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Cyclization/acylation reactions by nickel-catalyzed reactions of 1,6-ynal and 1,6-enyne derivatives with acylzirconocene chloride
TL;DR: In this paper, the primary formation of a metallacycle is followed by the transfer of an acyl group from the acylzirconocene complex (transmetalation).
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Patent
Ring-fused pyrazole derivative
Hiroki Umemiya,Hideaki Amada,Tetsuya Yabuuchi,Takeshi Koami,Fumiyasu Shiozawa,Yusuke Oka,Masakazu Sato +6 more
- 08 Mar 2007
TL;DR: A ring-fused pyrazole derivative represented by the formula (1) or a pharmaceutically acceptable salt thereof: (1), wherein n represents 2 or 3; A represents the formula: -O- or the like; B represents a C 1-10 alkylene group or the unlike; C represents a single bond or the formula, -O -; R1 represents a hydrogen atom, a pyrrolidinyl group or like; R4, R5 and R6 independently represent a hydrogen atoms, a halogen atom or a like; D1
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Acylzirconocene chloride : Formation of carbocycles by palladium-catalyzed cascade reaction
TL;DR: In this paper, the formation of carbocycles from ω-carbonyl α,β-enones was considered to be a result of a series of reactions; (i) an electron transfer from the Pd(0)-catalyst to an α, β-enone function in an initial step, (ii) an acyl group transfer from acylzirconocene complex to the pd(II)-intermediate (transmetalation), (iii) the reductive elimination of Pd (0)-metal, and (iv) an intramole
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A CONVENIENT SYNTHESIS OF 2-MERCAPTO-OXAZOLES VIA β-KETOAZIDE AND ITS APPLICATION TO A KEY INTERMEDIATE OF PI3Kγ INHIBITORS
TL;DR: A modified synthesis of 2-mercaptooxazoles (III) via an iminophosphorane-mediated reaction and its application to the multi-gram preparation of compound (IIIi), a key intermediate for PI3Kγ inhibitors, is reported in this paper.
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