Yusuke Maeda
Osaka University
5 Papers
129 Citations
Yusuke Maeda is an academic researcher from Osaka University. The author has contributed to research in topics: Golgi apparatus & Endoplasmic reticulum. The author has an hindex of 5, co-authored 5 publications.
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Papers
Mammalian GPI-anchored proteins require p24 proteins for their efficient transport from the ER to the plasma membrane.
TL;DR: This is the first to demonstrate direct evidence for the transport of mammalian GPI-anchored proteins being mediated by p24 proteins, and it is shown that maturation of DAF (decay-accelerating factor) was slowed by the suppression of p23, indicating delayed trafficking of Daf from the ER to the Golgi.
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Targeted therapy for inherited GPI deficiency.
Antonio Almeida,Yoshiko Murakami,Alastair Baker,Yusuke Maeda,Irene Roberts,Taroh Kinoshita,D. Mark Layton,Anastasios Karadimitris +7 more
TL;DR: The histone deacetylase inhibitor butyrate increases PIGM transcription and surface GPI expression in vitro as well as in vivo through enhanced histone acetylation in an Sp1-dependent manner and caused complete cessation of intractable seizures in a child with inherited GPI deficiency.
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Changes in molecular species profiles of glycosylphosphatidylinositol anchor precursors in early stages of biosynthesis.
Toshiaki Houjou,Jun Hayakawa,Reika Watanabe,Yuko Tashima,Yusuke Maeda,Taroh Kinoshita,Ryo Taguchi,Ryo Taguchi +7 more
TL;DR: The PI species profile greatly changed in the precursor glucosamine (GlcN)-acyl-PI and became very similar to that of GPI-APs before fatty acid remodeling, indicating that a specific feature of the PI moieties of mature GPI -APs, domination of alkyl (or alkenyl)/acyl type species over diacyl types, is established at the stage of GlcN-acyL-PI.
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Both mammalian PIG-M and PIG-X are required for growth of GPI14-disrupted yeast.
TL;DR: GPI-MT-I activity is not interchangeable between mammals and the other lower eukaryotes, and gpi14-disrupted yeast cells with human Pig-M, but not with PfPIG-M or TbGPI14, grew slowly but significantly when they were supplemented with rat PIG-X.
14
Fatty Acid Remodeling of GPI-anchored Proteins Is Required for Their Raft Association
Yusuke Maeda,Yuko Tashima,Toshiaki Houjou,Morihisa Fujita,Takehiko Yoko-o,Yoshifumi Jigami,Ryo Taguchi,Taroh Kinoshita +7 more
TL;DR: It is reported that GPI-APs, with two saturated fatty chains, are generated from those bearing an unsaturated chain by fatty acid remodeling that occurs most likely in the Golgi and requires post-GPI-attachment to proteins (PGAP)2 and PGAP3 and shows that the remodeling requires the preceding PGAP1-mediated deacylation from inositol of GPI -APs in the endoplasmic reticulum.