Yusuke Kuroda
Keio University
12 Papers
36 Citations
Yusuke Kuroda is an academic researcher from Keio University. The author has contributed to research in topics: Induced pluripotent stem cell & Internal medicine. The author has an hindex of 7, co-authored 12 publications. Previous affiliations of Yusuke Kuroda include Nagoya University.
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Papers
Endothelin-1 induces myofibrillar disarray and contractile vector variability in hypertrophic cardiomyopathy-induced pluripotent stem cell-derived cardiomyocytes
Atsushi Tanaka,Atsushi Tanaka,Shinsuke Yuasa,Giulia Mearini,Toru Egashira,Tomohisa Seki,Masaki Kodaira,Dai Kusumoto,Yusuke Kuroda,Shinichiro Okata,Shinichiro Okata,Tomoyuki Suzuki,Taku Inohara,Takuro Arimura,Shinji Makino,Kensuke Kimura,Akinori Kimura,Tetsushi Furukawa,Lucie Carrier,Koichi Node,Keiichi Fukuda +20 more
TL;DR: Interactions between the patient's genetic backgrounds and the environmental factor endothelin‐1 promote the HCM pathological phenotype and contractile variability in the H CM iPSC‐derived cardiomyocytes.
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Impaired respiratory function in MELAS-induced pluripotent stem cells with high heteroplasmy levels
Masaki Kodaira,Hideyuki Hatakeyama,Shinsuke Yuasa,Tomohisa Seki,Toru Egashira,Shugo Tohyama,Yusuke Kuroda,Atsushi Tanaka,Shinichiro Okata,Hisayuki Hashimoto,Dai Kusumoto,Akira Kunitomi,Makoto Takei,Shin Kashimura,Tomoyuki Suzuki,Gakuto Yozu,Masaya Shimojima,Chikaaki Motoda,Nozomi Hayashiji,Yuki Saito,Yu-ichi Goto,Keiichi Fukuda +21 more
TL;DR: The data indicate that M ELAS‐iPSCs can be models for MELAS but they should be carefully selected with appropriate heteroplasmy levels and respiratory functions for mitochondrial disease modeling.
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Generation and Characterization of Functional Cardiomyocytes Derived from Human T Cell-Derived Induced Pluripotent Stem Cells
Tomohisa Seki,Shinsuke Yuasa,Dai Kusumoto,Akira Kunitomi,Yuki Saito,Shugo Tohyama,Kojiro Yae,Yoshikazu Kishino,Marina Okada,Hisayuki Hashimoto,Makoto Takei,Toru Egashira,Masaki Kodaira,Yusuke Kuroda,Atsushi Tanaka,Shinichiro Okata,Tomoyuki Suzuki,Mitsushige Murata,Jun Fujita,Keiichi Fukuda +19 more
TL;DR: It is shown that TiPSCs successfully differentiated into cardiomyocytes with morphology, gene expression patterns, and electrophysiological features typical of native cardiomeocytes, which could become disease models for understanding the mechanisms of cardiac disease and cell sources for revolutionaryCardiomyocyte therapies.
Potential Benefit of Bachmann’s Bundle Pacing on Left Ventricular Performance in Patients With Cardiac Resynchronized Therapy
Tomoyuki Suzuki,Toshiyuki Osaka,Yusuke Kuroda,Hideyuki Hasebe,Eriko Yokoyama,Kaichiro Kamiya,Itsuo Kodama +6 more
TL;DR: BB pacing preserves atrial synchrony, and might be more favorable than RAA pacing for maximizing hemodynamic efficacy of CRT, and was associated with significant improvement of LV performance.
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Opposing effects of bepridil on ventricular repolarization in humans. Inhomogeneous prolongation of the action potential duration vs flattening of its restitution kinetics.
Toshiyuki Osaka,Eriko Yokoyama,Yasunori Kushiyama,Hideyuki Hasebe,Yusuke Kuroda,Tomoyuki Suzuki,Itsuo Kodama +6 more
TL;DR: Bepridil produces an inhomogeneous prolongation of the MAPDs, but flattens their restitution kinetics in the human ventricle as well as reducing the dynamic instability of the repolarization.
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