Yusuke Kimura
Ritsumeikan University
5 Papers
1 Citations
Yusuke Kimura is an academic researcher from Ritsumeikan University. The author has contributed to research in topics: Homologous recombination & DNA repair. The author has an hindex of 2, co-authored 4 publications.
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Papers
The deubiquitylating enzyme UCHL3 regulates Ku80 retention at sites of DNA damage.
Ryotaro Nishi,Ryotaro Nishi,Paul W. G. Wijnhoven,Paul W. G. Wijnhoven,Yusuke Kimura,Misaki Matsui,Rebecca Konietzny,Qian Wu,Keisuke Nakamura,Tom L. Blundell,Benedikt M. Kessler +10 more
TL;DR: UCHL3 facilitates cellular viability after DSB induction by antagonizing Ku80 ubiquitylation to enhance Ku80 retention at sites of damage, and this phosphorylation destabilizes UCHL3, despite having no effect on its catalytic activity.
Mito-FUNCAT-FACS reveals cellular heterogeneity in mitochondrial translation
Yusuke Kimura,Hironori Saito,Tatsuya Osaki,Yasuhiro Ikegami,Taisei Wakigawa,Yoshiho Ikeuchi,Shintaro Iwasaki +6 more
TL;DR: The application of in situ mito-FUNCAT to flow cytometry allowed us to disentangle changes in net mitochondrial translation activity from those of the organelle mass and detect variations in mitochondrial translation in cancer cells.
A novel nuclear speckle factor, USP42, promotes homologous recombination repair by resolving DNA double-strand break induced R-loop
Misaki Matsui,Ryo Sakasai,Masako Abe,Yusuke Kimura,Shoki Kajita,Wakana Torii,Yoko Katsuki,Masamichi Ishiai,Kuniyoshi Iwabuchi,Minoru Takata,Ryotaro Nishi +10 more
TL;DR: A model is proposed in which a novel nuclear speckle factor, USP42, facilitates DSB-induced R-loop resolution, BRCA1 loading to DSB sites and preferential DSB repair by HR, indicating the importance of spatial regulation of D SB repair choice mediated by nuclear bodies.
USP42 enhances homologous recombination repair by promoting R-loop resolution with a DNA-RNA helicase DHX9.
Misaki Matsui,Ryo Sakasai,Masako Abe,Yusuke Kimura,Shoki Kajita,Wakana Torii,Yoko Katsuki,Masamichi Ishiai,Kuniyoshi Iwabuchi,Minoru Takata,Ryotaro Nishi,Ryotaro Nishi +11 more
- 15 Jun 2020
TL;DR: A model in which USP42 facilitates BRCA1 loading to DSB sites, resolution of DSB-induced R-loop and preferential DSB repair by HR is proposed, indicating the importance of nuclear speckle-mediated regulation of D SB repair.