Yunwei Chen
Illinois Institute of Technology
18 Papers
155 Citations
Yunwei Chen is an academic researcher from Illinois Institute of Technology. The author has contributed to research in topics: Bifunctional & Radioimmunotherapy. The author has an hindex of 8, co-authored 18 publications.
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Papers
Synthesis and preclinical evaluation of bifunctional ligands for improved chelation chemistry of 90Y and 177Lu for targeted radioimmunotherapy.
TL;DR: 3p-C-NETA possesses favorable in vitro and in vivo profiles and is an excellent bifunctional chelator that can be used for targeted RIT applications using (90)Y and (177)Lu and has the potential to replace DOTA and DTPA analogues in current clinical use.
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Efficient bifunctional decadentate ligand 3p-C-DEPA for targeted α-radioimmunotherapy applications.
Hyun A. Song,Chi Soo Kang,Kwamena E. Baidoo,Diane E. Milenic,Yunwei Chen,Anzhi Dai,Martin W. Brechbiel,Hyun-Soon Chong +7 more
TL;DR: The results of the in vitro and in vivo studies indicate that 3p-C-DEPA is a promising chelator for radioimmunotherapy of (212)Bi and (213)Bi.
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Synthesis and evaluation of a new bifunctional NETA chelate for molecular targeted radiotherapy using90Y or177Lu
Chi Soo Kang,Yunwei Chen,Hyunbeom Lee,Dijie Liu,Xiang Sun,Junghun Kweon,Michael R. Lewis,Hyun-Soon Chong +7 more
TL;DR: The results of in vitro and in vivo evaluation suggest that 5p-C-NETA is an effective bifunctional chelate of (90)Y and (177)Lu that can be applied for generation of versatile molecular targeted radiopharmaceuticals.
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A highly effective bifunctional ligand for radioimmunotherapy applications.
Hyun-Soon Chong,Hyun A. Song,Chi Soo Kang,Thien Le,Xiang Sun,Mamta Dadwal,Hyunbeom Lee,Xiaoli Lan,Yunwei Chen,Anzhi Dai +9 more
TL;DR: 3p-C-NETA instantly formed a very stable complex with (90)Y or (177)Lu and is an excellent bifunctional ligand for RIT.
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Synthesis and comparative biological evaluation of bifunctional ligands for radiotherapy applications of (90)Y and (177)Lu.
Hyun-Soon Chong,Xiang Sun,Yunwei Chen,Inseok Sin,Chi Soo Kang,Michael R. Lewis,Dijie Liu,Varyanna C. Ruthengael,Yongliang Zhong,Ningjie Wu,Hyun A. Song +10 more
TL;DR: Comparisons of the comparative complexation kinetic and stability studies indicate that size of macrocyclic cavity, ligand denticity, and bimodality of donor groups have a substantial impact on complexation of the bifunctional ligands with the radiolanthanides.
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