Yunlong He
Leidos
12 Papers
13 Citations
Yunlong He is an academic researcher from Leidos. The author has contributed to research in topics: Epigenetics & Induced pluripotent stem cell. The author has an hindex of 10, co-authored 12 publications. Previous affiliations of Yunlong He include National Institutes of Health & Shanghai Jiao Tong University.
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Papers
Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
TL;DR: A whole-genome study of p53-mediated DNA damage signaling in mouse ES cells supports a model where, in response to DNA damage, p53 affects the status of ES cells through activating differentiation-associated genes and repressing ES cell-enriched genes.
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Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines.
Feng Liu,Dalia Barsyte-Lovejoy,Abdellah Allali-Hassani,Yunlong He,J. Martin Herold,Xin Chen,Christopher M. Yates,Stephen V. Frye,Peter Brown,Jing Huang,Masoud Vedadi,Cheryl H. Arrowsmith,Jian Jin +12 more
TL;DR: A number of novel G9a inhibitors such as UNC0646 and UNC0631 are discovered with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity.
Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.
TL;DR: This work provides a more specific strategy for the cloning of modular type I PKS gene clusters and paves the way for its pathway engineering in meilingmycin.
44
Fatty acid oxidation is required for embryonic stem cell survival during metabolic stress
Hualong Yan,Navdeep Malik,Young-Im Kim,Yunlong He,Mangmang Li,Mangmang Li,Wendy Dubois,Huaitian Liu,Tyler J Peat,Joe T Nguyen,Yu-Chou Tseng,Gamze Ayaz,Waseem Alzamzami,King C. Chan,Thorkell Andresson,Lino Tessarollo,Beverly A. Mock,Maxwell P. Lee,Jing Huang +18 more
TL;DR: In this paper, an unexpected role of Tfcp2l1 in metabolic regulation in ESCs was reported, which promoted the survival of ESCs through regulating fatty acid oxidation (FAO) under metabolic stress.
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Embryonic stem cells shed new light on the developmental roles of p53.
TL;DR: The molecular mechanisms underlying the developmental role of p53 are emerging, and the developmental roles and tumor suppressive function of p 53 may be closely related.