5 Papers
4 Citations
Yun Lu is an academic researcher from China Agricultural University. The author has contributed to research in topics: Proinflammatory cytokine & Microglia. The author has an hindex of 4, co-authored 5 publications.
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Papers
CD36 Participates in PrP106–126-Induced Activation of Microglia
Mohammed Kouadir,Lifeng Yang,Rongrong Tan,Fushan Shi,Yun Lu,Siming Zhang,Xiaomin Yin,Xiangmei Zhou,Deming Zhao +8 more
TL;DR: In this paper, the role of the class B scavenger receptor CD36 in microglial activation induced by neurotoxic prion protein fragment 106-126 (PrP(106-126)).
PP2 and piceatannol inhibit PrP106-126-induced iNOS activation mediated by CD36 in BV2 microglia.
Siming Zhang,Lifeng Yang,Mohammed Kouadir,Rongrong Tan,Yun Lu,Jiaxin Chang,Binrui Xu,Xiaomin Yin,Xiangmei Zhou,Deming Zhao +9 more
TL;DR: It is shown that CD36 is involved in PrP106-126-induced microglial activation and that PP2 and piceatannol (Pic) can abrogate neurotoxic prion peptides-induced inducible nitric oxide synthase activation in microglia.
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Correction: CD36 Participates in PrP106–126-Induced Activation of Microglia.
Mohammed Kouadir,Lifeng Yang,Rongrong Tan,Fushan Shi,Yun Lu,Siming Zhang,Xiaomin Yin,Xiangmei Zhou,Deming Zhao +8 more
TL;DR: This work was supported by the Ministry of Agriculture, Key Program, China, and the Program for Cheung Kong Scholars and Innovative Research Team in University of China.
5
Mycobacterium bovis ornithine carbamoyltransferase, MB1684, induces proinflammatory cytokine gene expression by activating NF-κB in macrophages.
Wei Zhao,Xiangmei Zhou,Yun Lu,Yun Peng,Zhu Lin,Jingjun Lin,Lifeng Yang,Xiaomin Yin,Deming Zhao +8 more
TL;DR: A concentration-dependent decrease in proliferation of Ana-1 macrophages is confirmed when treated with rMB1684 when compared with mycobacterium bovis purified protein derivative of tuberculosis (MbPPD) or phosphate buffer solution incubation groups.
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Prion peptide PrP106-126 induces inducible nitric oxide synthase and proinflammatory cytokine gene expression through the activation of NF-κB in macrophage cells.
Yun Lu,Ailing Liu,Xiangmei Zhou,Mohammed Kouadir,Wei Zhao,Siming Zhang,Xiaomin Yin,Lifeng Yang,Deming Zhao +8 more
TL;DR: The results suggest that treatment with neurotoxic prion peptides leads to the activation of transcription factor NF-κB, which in turn stimulates gene expression of iNOS and proinflammatory cytokines in Ana-1 macrophages.