Yumiko Gomei
Keio University
9 Papers
Yumiko Gomei is an academic researcher from Keio University. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 9, co-authored 9 publications.
Chat about Author
Papers
Thrombopoietin/MPL Signaling Regulates Hematopoietic Stem Cell Quiescence and Interaction with the Osteoblastic Niche
Hiroki Yoshihara,Fumio Arai,Kentaro Hosokawa,Tetsuya Hagiwara,Keiyo Takubo,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Sahoko Matsuoka,Kana Miyamoto,Hiroshi Miyazaki,Takao Takahashi,Toshio Suda +12 more
TL;DR: It is shown that the long-term (LT)-HSCs expressing the thrombopoietin (THPO) receptor, MPL, are a quiescent population in adult bone marrow and are closely associated with THPO-producing osteoblastic cells, suggesting that THPO/MPL signaling plays a critical role of LT-HSC regulation in the osteoblastics niche.
816
Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
Kentaro Hosokawa,Fumio Arai,Hiroki Yoshihara,Hiroko Iwasaki,Yuka Nakamura,Yumiko Gomei,Toshio Suda +6 more
TL;DR: N-cad-mediated cell adhesion is functionally required for the establishment of hematopoiesis in the BM niche after BM transplantation, suggesting that N- cadherin for HSPC engraftment appears to be niche specific.
131
Cadherin-Based Adhesion Is a Potential Target for Niche Manipulation to Protect Hematopoietic Stem Cells in Adult Bone Marrow
Kentaro Hosokawa,Fumio Arai,Hiroki Yoshihara,Hiroko Iwasaki,Mark Hembree,Tong Yin,Yuka Nakamura,Yumiko Gomei,Keiyo Takubo,Haruko Shiama,Sahoko Matsuoka,Linheng Li,Toshio Suda +12 more
TL;DR: The expression of various cadherin (cad) genes in long-term HSCs (LT-HSCs) and subpopulations of the cells isolated from the endosteum are analyzed.
100
Niche Regulation of Hematopoietic Stem Cells in the Endosteum
Fumio Arai,Hiroki Yoshihara,Kentaro Hosokawa,Yuka Nakamura,Yumiko Gomei,Hiroko Iwasaki,Toshio Suda +6 more
TL;DR: It is suggested that inhibiting the HSC–niche interaction could represent a novel technique for bone marrow transplantation without irradiation, and in the steady‐state condition, this signaling pathway plays a critical role in the regulation of LT‐HSCs in the osteoblastic niche.
74
Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells.
Yumiko Gomei,Yuka Nakamura,Hiroki Yoshihara,Kentaro Hosokawa,Hiroko Iwasaki,Toshio Suda,Fumio Arai +6 more
TL;DR: The data suggest that angiopoietin-1 is a dominant ligand for the Tie2 receptor in long HSCs in BM, and reversed the effects of Ang-1/Tie2 signaling in the regulation of long-term H SCs.
48