Yuling Han
Cornell University
21 Papers
21 Citations
Yuling Han is an academic researcher from Cornell University. The author has contributed to research in topics: Medicine & Induced pluripotent stem cell. The author has an hindex of 9, co-authored 13 publications. Previous affiliations of Yuling Han include Chinese Academy of Sciences.
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Papers
A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids.
Liuliu Yang,Yuling Han,Benjamin E. Nilsson-Payant,Vikas Gupta,Pengfei Wang,Xiaohua Duan,Xiaohua Duan,Xuming Tang,Jiajun Zhu,Zeping Zhao,Fabrice Jaffré,Tuo Zhang,Tae Wan Kim,Oliver Harschnitz,David Redmond,Sean Houghton,Chengyang Liu,Ali Naji,Gabriele Ciceri,Sudha R Guttikonda,Yaron Bram,Duc-Huy T. Nguyen,Michele Cioffi,Vasuretha Chandar,Daisy A. Hoagland,Yaoxing Huang,Jenny Xiang,Hui Wang,Hui Wang,David Lyden,Alain C. Borczuk,Huanhuan Joyce Chen,Lorenz Studer,Fong Cheng Pan,David D. Ho,Benjamin R. tenOever,Todd Evans,Robert E. Schwartz,Shuibing Chen +38 more
TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.
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Identification of SARS-CoV-2 inhibitors using lung and colonic organoids.
Yuling Han,Xiaohua Duan,Xiaohua Duan,Liuliu Yang,Benjamin E. Nilsson-Payant,Pengfei Wang,Fuyu Duan,Xuming Tang,Tomer M. Yaron,Tuo Zhang,Skyler Uhl,Yaron Bram,Chanel Richardson,Jiajun Zhu,Zeping Zhao,David Redmond,Sean Houghton,Duc-Huy T. Nguyen,Dong Xu,Xing Wang,Jose Jessurun,Alain C. Borczuk,Yaoxing Huang,Jared L. Johnson,Yuru Liu,Jenny Xiang,Hui Wang,Lewis C. Cantley,Benjamin R. tenOever,David D. Ho,Fong Cheng Pan,Todd Evans,Huanhuan Joyce Chen,Huanhuan Joyce Chen,Robert E. Schwartz,Shuibing Chen +35 more
TL;DR: This work developed a lung organoid model using human pluripotent stem cells (hPSC-LOs) and performed a high-throughput screen of drugs approved by the FDA and identified entry inhibitors of SARS-CoV-2, including imatinib, mycophenolic acid and quinacrine dihydrochloride.
Identification of Candidate COVID-19 Therapeutics using hPSC-derived Lung Organoids
Yuling Han,Liuliu Yang,Xiaohua Duan,Fuyu Duan,Benjamin E. Nilsson-Payant,Tomer M. Yaron,Pengfei Wang,Xuming Tang,Tuo Zhang,Zeping Zhao,Yaron Bram,David Redmond,Sean Houghton,Duc T. Nguyen,Dong Xu,Xing Wang,Skyler Uhl,Yaoxing Huang,Jared L. Johnson,Jenny Xiang,Hui Wang,Fong Cheng Pan,Lewis C. Cantley,Benjamin R. tenOever,David D. Ho,Todd Evans,Robert E. Schwartz,Huanhuan Joyce Chen,Shuibing Chen +28 more
TL;DR: It is demonstrated that hPSC-derived lung cells infected by SARS-CoV-2 can model human COVID-19 disease and provide a valuable resource to screen for FDA-approved drugs that might be repurposed and should be considered for CO VID-19 clinical trials.
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Regulation of HIV-1 Gag-Pol Expression by Shiftless, an Inhibitor of Programmed -1 Ribosomal Frameshifting.
Xinlu Wang,Yifang Xuan,Yuling Han,Xiang Ding,Kai Ye,Fuquan Yang,Pu Gao,Stephen P. Goff,Guangxia Gao +8 more
TL;DR: This work reports that the interferon-stimulated gene product C19orf66 (herein named Shiftless) is a host factor that inhibits the -1PRF of HIV-1 and proposes that SFL binding to target mRNA and the translating ribosome interferes with the framing process.
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Human organoid models to study SARS-CoV-2 infection
TL;DR: In this article , the authors overview the current effort to apply both human pluripotent stem cell-derived organoids and adult organoids to study SARS-CoV-2 tropism, host response and immune cell-mediated host damage, and perform drug discovery and vaccine development.
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