Yuko Ohnuma
University of Yamanashi
16 Papers
189 Citations
Yuko Ohnuma is an academic researcher from University of Yamanashi. The author has contributed to research in topics: Thymic stromal lymphopoietin & Allergic inflammation. The author has an hindex of 13, co-authored 16 publications.
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Papers
Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to TH2-type immune responses and airway inflammation
Yuki Nakamura,Masanori Miyata,Tetsuro Ohba,Takashi Ando,Kyosuke Hatsushika,Fumiko Suenaga,Naomi Shimokawa,Yuko Ohnuma,Ryohei Katoh,Hideoki Ogawa,Atsuhito Nakao,Atsuhito Nakao +11 more
TL;DR: CSE induced TSLP expression in the mouse lung in an oxidative stress-dependent and TNF-alpha receptor I-dependent manner, and when challenged simultaneously with an antigen, CSE promoted the development of airway inflammation in association with T(H)2-type immune responses.
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Mast cell regulation of epithelial TSLP expression plays an important role in the development of allergic rhinitis.
Masanori Miyata,Kyosuke Hatsushika,Takashi Ando,Naomi Shimokawa,Yuko Ohnuma,Ryohei Katoh,Hajime Suto,Hideoki Ogawa,Keisuke Masuyama,Atsuhito Nakao,Atsuhito Nakao +10 more
TL;DR: The results suggest that the direct stimulation of epithelial cells by antigens alone may not be sufficient to induce TSLP expression in the nasal epithelium, and that mast cell regulation of epitheric TSLp expression, possibly via FcϵRI, plays an important role in the development of allergic rhinitis.
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Thymic stromal lymphopoietin secretion of synovial fibroblasts is positively and negatively regulated by Toll-like receptors/nuclear factor-κB pathway and interferon-γ/dexamethasone
Tetsuro Ozawa,Kensuke Koyama,Takashi Ando,Yuko Ohnuma,Kyosuke Hatsushika,Tetsuro Ohba,Hajime Sugiyama,Yoshiki Hamada,Hideoki Ogawa,Ko Okumura,Atsuhito Nakao,Atsuhito Nakao +11 more
TL;DR: The current findings suggest that TSLP may be involved in the pathophysiology of inflammatory arthritis as well as allergic disease.
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Thymic stromal lymphopoietin is a critical mediator of IL‐13‐driven allergic inflammation
Masanori Miyata,Yuki Nakamura,Naomi Shimokawa,Yuko Ohnuma,Ryohei Katoh,Shuji Matsuoka,Ko Okumura,Hideoki Ogawa,Keisuke Masuyama,Atsuhito Nakao,Atsuhito Nakao +10 more
TL;DR: TSLP may function both upstream and downstream of IL‐13, thus providing an additional rationale as to why TSLP plays such a central role in the development of allergic inflammation.
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A potential role of thymic stromal lymphopoietin in the recruitment of macrophages to mouse intervertebral disc cells via monocyte chemotactic protein 1 induction: Implications for herniated discs
Tetsuro Ohba,Hirotaka Haro,Takashi Ando,Kensuke Koyama,Kyosuke Hatsushika,Fumiko Suenaga,Yuko Ohnuma,Yuki Nakamura,Ryohei Katoh,Hideoki Ogawa,Yoshiki Hamada,Atsuhito Nakao +11 more
TL;DR: TSLP induced by NF-kappaB-activating ligands in intervertebral discs may contribute to the recruitment of macrophages to the interverTEbral disc by stimulating MCP-1 production and may be involved in the resorption of herniated disc tissue.
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