Yuko Nagayasu
Nagoya City University
26 Papers
324 Citations
Yuko Nagayasu is an academic researcher from Nagoya City University. The author has contributed to research in topics: Apolipoprotein E & Cholesterol. The author has an hindex of 13, co-authored 26 publications.
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Papers
Apolipoprotein A-I induces translocation of cholesterol, phospholipid, and caveolin-1 to cytosol in rat astrocytes.
TL;DR: The findings suggest that translocation of cholesterol and phospholipid into the cytosol is related to the apo A-I-mediated HDL assembly in astrocytes through functional association with caveolin-1 and a cyclosporin A-sensitive cyclophilin protein(s).
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Recruitment of miR-8080 by luteolin inhibits androgen receptor splice variant 7 expression in castration-resistant prostate cancer.
Aya Naiki-Ito,Taku Naiki,Hiroyuki Kato,Keitaro Iida,Toshiki Etani,Yuko Nagayasu,Shugo Suzuki,Yoriko Yamashita,Shingo Inaguma,Masaya Onishi,Yasuhito Tanaka,Takahiro Yasui,Satoru Takahashi +12 more
TL;DR: Investigation of the chemopreventive and chemotherapeutic potential of luteolin, a flavonoid with antioxidative properties, on prostate cancer, including castration-resistant prostate cancer shows results that indicate lutingolin inhibits CRPC by AR-V7 suppression through miR-8080, highlighting lutesolin and miR -8080 as promising therapeutic agents for this disease.
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Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action.
TL;DR: Results are consistent with the in vivo observation that astrocytes produce FGF-1 before the increase of apolipoprotein E in the postinjury lesion of the mouse brain and promote apoE-HDL production by an autocrine mechanism.
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Apolipoprotein-mediated Cellular Lipid Release Requires Replenishment of Sphingomyelin in a Phosphatidylcholine-specific Phospholipase C-dependent Manner
TL;DR: It is concluded that removal of cellular sphingomyelin by apolipoproteins is replenished by transfer of phosphorylcholine from phosphatidylcholine to ceramide, and this reaction may limit the removal of cholesterol by apoA-I.
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Astrocyte׳s endogenous apoE generates HDL-like lipoproteins using previously synthesized cholesterol through interaction with ABCA1
TL;DR: It is indicated that the endogenous apoE participates in the release of previously synthesized cholesterol but not newly synthesized one, and lower density HDL is generated through the interaction with ABCA1 in caveolin-1-rich domain of astrocytes.
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