Yukio Sugiura
Kyoto University
283 Papers
4.4K Citations
Yukio Sugiura is an academic researcher from Kyoto University. The author has contributed to research in topics: Zinc finger & DNA. The author has an hindex of 49, co-authored 277 publications. Previous affiliations of Yukio Sugiura include Fukuyama University & Osaka University.
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Papers
An artificial six-zinc finger peptide with polyarginine linker: selective binding to the discontinuous DNA sequences.
TL;DR: It is demonstrated that polyarginine linker between two 3-zinc finger domains gives DNA binding selectivity to the separated target sequences.
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An arginine residue instead of a conserved leucine residue in the recognition helix of the finger 3 of Zif268 stabilizes the domain structure and mediates DNA binding.
TL;DR: Results demonstrate that, as with the Leu residue, the aliphatic carbon side chain of this Arg residue plays a key role in the formation of a stable zinc finger domain, and its terminal guanidinium group appears to be essential for DNA binding mediated through both electrostatic interaction and hydrogen bonding with DNA phosphate backbone.
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Participation of Oligomerization through C-Terminal D Domain Region of Sp1 in DNA Binding
TL;DR: Gel mobility shift assays demonstrate that Sp1 evidently shows DNA-binding modes different from Spl and that the Sp1 mutant containing the domain D self-interacts directly, and Domain D may play an important role in the synergistic activation of Sp1 by the stacking of tetramers.
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