Yukio Sugiura
Kyoto University
283 Papers
4.4K Citations
Yukio Sugiura is an academic researcher from Kyoto University. The author has contributed to research in topics: Zinc finger & DNA. The author has an hindex of 49, co-authored 277 publications. Previous affiliations of Yukio Sugiura include Fukuyama University & Osaka University.
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Papers
Metal-stimulated regulation of transcription by an artificial zinc-finger protein.
TL;DR: A zinc-finger protein was designed by substituting the second zinc- Finger motif of wtZF3 into the CDH2-ZF 3 and it was found that the binding affinity to Zn would decrease and that it would then be possible to control the DNA binding ability of the peptide through changes in the Zn concentration.
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The past, present, and future of artificial zinc finger proteins: design strategies and chemical and biological applications
Shigeru Negi,Miki Imanishi,Mami Hamori,Yuka Kawahara-Nakagawa,Wataru Nomura,Kanae Kishi,Nobuhito Shibata,Yukio Sugiura +7 more
- 07 Feb 2023
TL;DR: A review of previous studies on the redesign and application of artificial zinc finger proteins can be found in this article , focusing on the experimental results obtained by our research group and discuss their potential biological applications, including gene editing.
Cobalt and ruthenium replacement for iron in adrenal iron-sulfur protein (adrenodoxin). Preparation and some properties.
TL;DR: The Co- and Ru-substituted derivatives of adrenal iron-sulfur protein (adrenodoxin) were prepared from its apoprotein in the presence of urea, dithiothreitol, Na2S, and metal ions and revealed that the saturation levels are 8.6 and 8.4 mol of mercurial/mol of protein.
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Novel zinc finger nuclease created by combining the Cys2His2- and His4-type zinc finger domains
TL;DR: The gel mobility shift assay demonstrated that ZWH4 binds to the GC box DNA, although the DNA-binding affinity is lower than that of Sp1(zf123).
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Studies on the Sulfur-containing Chelating Agents. XXXIII. Interaction of Penicillamine and Its Related Compounds with Chromium Ion and Hemoglobin-bound Chromium
TL;DR: In this paper, the effects of chelating agents containing sulfhydryl group on the removal of chromium bound to hemoglobin were compared with those of ascorbic acid and EDTA, and the sulfur-containing ligands were superior to those of the other ligands, in the rate and the amount of the removal.
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