Yuki Ouchi
Hokkaido University
5 Papers
2 Citations
Yuki Ouchi is an academic researcher from Hokkaido University. The author has contributed to research in topics: DNA gyrase & Chemistry. The author has an hindex of 2, co-authored 5 publications.
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Papers
WQ-3810: A new fluoroquinolone with a high potential against fluoroquinolone-resistant Mycobacterium tuberculosis.
Yuki Ouchi,Tetsu Mukai,Kentaro Koide,Tomoyuki Yamaguchi,Jong-Hoon Park,Hyun Kim,Kazumasa Yokoyama,Aki Tamaru,Stephen V. Gordon,Chie Nakajima,Yasuhiko Suzuki +10 more
TL;DR: WQ-3810 might represent a new, potent anti-tuberculosis drug that can be effective even against FQ-resistant Mtb strains, since FQs and ethambutol have been used in multi-drug therapy for tuberculosis.
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WQ-3810 inhibits DNA gyrase activity in ofloxacin-resistant Mycobacterium leprae.
Jong-Hoon Park,Tomoyuki Yamaguchi,Yuki Ouchi,Kentaro Koide,Shigetarou Mori,Hyun Kim,Tetsu Mukai,Chie Nakajima,Yasuhiko Suzuki +8 more
TL;DR: Using interactions like the one found in the present work may help design new fluoroquinolones that contribute to halt the emergence of antibiotic-resistant pathogens.
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Amino Acid Substitution Ser83Ile in GyrA of DNA Gyrases Confers High-Level Quinolone Resistance to Nontyphoidal Salmonella Without Loss of Supercoiling Activity.
Kentaro Koide,Lai Lai San,Ruttana Pachanon,Jong-Hoon Park,Yuki Ouchi,Siriporn Kongsoi,Fuangfa Utrarachkij,Chie Nakajima,Yasuhiko Suzuki +8 more
TL;DR: A Quinolone-resistant nontyphoidal Salmonella having serine replaced by isoleucine at the 83rd amino acid in GyrA (GyrA-Ser83Ile) has recently been found in Asian countries.
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Antibacterial Activity of DC-159a Against Salmonella Typhimurium
Kentaro Koide,Siriporn Kongsoi,Siriporn Kongsoi,Yuki Ouchi,Tomoyuki Yamaguchi,Chie Nakajima,Yasuhiko Suzuki +6 more
TL;DR: In vitro, the activity of DC-159a against Salmonella enterica serovar Typhimurium with that of ciprofloxacin and nalidixic acid was compared and it was suggested as an antibiotic candidate for treating salmonellosis caused by quinolone-resistant S. TyphIMurium.
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Interaction of Quinolones Carrying New R1 Group with Mycobacterium leprae DNA Gyrase
Jong-Hoon Park,Tomoyuki Yamaguchi,Yuki Ouchi,Kentaro Koide,Ruttana Pachanon,Joseph Yamweka Chizimu,Joseph Yamweka Chizimu,Shigetarou Mori,Hyun Kim,Tetsu Mukai,Chie Nakajima,Yasuhiko Suzuki +11 more
TL;DR: In this paper, specific amino acid substitutions in DNA gyrase of Mycobacterium leprae have been found to have been associated with Leprosy.
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