Yujiro Yamamoto
4 Papers
Yujiro Yamamoto is an academic researcher. The author has contributed to research in topics: Exome sequencing & Liver cancer. The author has an hindex of 4, co-authored 4 publications.
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Papers
Genomic characterization of biliary tract cancers identifies driver genes and predisposing mutations.
Christopher P. Wardell,Masashi Fujita,Toru Yamada,Michele Simbolo,Matteo Fassan,Rosa Karlic,Paz Polak,Jaegil Kim,Yutaka Hatanaka,Kazuhiro Maejima,Rita T. Lawlor,Yoshitsugu Nakanishi,Tomoko Mitsuhashi,Akihiro Fujimoto,Mayuko Furuta,Andrea Ruzzenente,Simone Conci,Ayako Oosawa,Aya Sasaki-Oku,Kaoru Nakano,Hiroko Tanaka,Yujiro Yamamoto,Kubo Michiaki,Yoshiiku Kawakami,Hiroshi Aikata,Masaki Ueno,Shinya Hayami,Kunihito Gotoh,Shunichi Ariizumi,Masakazu Yamamoto,Hiroki Yamaue,Kazuaki Chayama,Satoru Miyano,Gad Getz,Aldo Scarpa,Satoshi Hirano,Toru Nakamura,Hidewaki Nakagawa +37 more
TL;DR: Large-scale genome sequencing analyses on biliary tract cancers suggest cell-of-origin predictions using WGS and epigenetic features suggest hepatocyte-origin of hepatitis-related ICCs, and these findings could be useful to establish treatment and diagnostic strategies for BTCs based on genetic information.
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Whole-genome mutational landscape of liver cancers displaying biliary phenotype reveals hepatitis impact and molecular diversity
Akihiro Fujimoto,Mayuko Furuta,Yuichi Shiraishi,Kunihito Gotoh,Yoshiiku Kawakami,Koji Arihiro,Toru Nakamura,Masaki Ueno,Shunichi Ariizumi,Ha Hai Nguyen,Daichi Shigemizu,Tetsuo Abe,Keith A. Boroevich,Kaoru Nakano,Aya Sasaki,Rina Kitada,Kazihiro Maejima,Yujiro Yamamoto,Hiroko Tanaka,Tetsuo Shibuya,Tatsuhiro Shibata,Hidenori Ojima,Kazuaki Shimada,Shinya Hayami,Yoshinobu Shigekawa,Hiroshi Aikata,Hideki Ohdan,Shigeru Marubashi,Terumasa Yamada,Michiaki Kubo,Satoshi Hirano,Osamu Ishikawa,Masakazu Yamamoto,Hiroki Yamaue,Kazuaki Chayama,Satoru Miyano,Tatsuhiko Tsunoda,Hidewaki Nakagawa +37 more
TL;DR: The genome-wide substitution patterns of LCBs developed in chronic hepatitis livers overlapped with those of 60 HCCs, whereas those of hepatitis-negative LCBs diverged, revealing the strong impact of chronic hepatitis on the mutational landscape in liver cancer and the genetic diversity among LCBs.
Circulating Tumor DNA Analysis for Liver Cancers and Its Usefulness as a Liquid Biopsy
Atsushi Ono,Akihiro Fujimoto,Yujiro Yamamoto,Sakura Akamatsu,Nobuhiko Hiraga,Michio Imamura,Tomokazu Kawaoka,Masataka Tsuge,Hiromi Abe,C. Nelson Hayes,Daiki Miki,Mayuko Furuta,Tatsuhiko Tsunoda,Satoru Miyano,Michiaki Kubo,Hiroshi Aikata,Hidenori Ochi,Yoshi iku Kawakami,Koji Arihiro,Hideki Ohdan,Hidewaki Nakagawa,Kazuaki Chayama +21 more
TL;DR: The usefulness of ctDNA detection and sequencing analysis of cell-free DNA for personalized treatment of liver cancer is demonstrated and can predict VP and recurrence, especially extrahepatic metastasis within 2 years.
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A Practical Method to Detect SNVs and Indels From Whole Genome and Exome Sequencing Data
Daichi Shigemizu,Akihiro Fujimoto,Shintaro Akiyama,Tetsuo Abe,Kaoru Nakano,Keith A. Boroevich,Yujiro Yamamoto,Mayuko Furuta,Michiaki Kubo,Hidewaki Nakagawa,Tatsuhiko Tsunoda +10 more
TL;DR: A probabilistic multinomial method for the detection of single nucleotide variants (SNVs) as well as short insertions and deletions (indels) in whole genome sequencing and whole exome sequencing data for single sample calling is developed.