Yuji Ishikawa
Kanazawa University
10 Papers
198 Citations
Yuji Ishikawa is an academic researcher from Kanazawa University. The author has contributed to research in topics: Phosphorylation & Peptide. The author has an hindex of 8, co-authored 10 publications.
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Papers
Molecular mechanism of interleukin-8 gene expression
TL;DR: Although several leukocyte chemotactic factors including C5a, leukotriene B4 have long been identified, these factors have chemotactactic activities for any kind of leukocytes.
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Novel mechanism of glucocorticoid-mediated gene repression. Nuclear factor-kappa B is target for glucocorticoid-mediated interleukin 8 gene repression.
TL;DR: Collectively, dexamethasone interfered with the binding of the most essential transcription factor, NF-kappa B, to its cognate cis-element, thereby suppressing the transcription of IL-8 gene.
446
The interleukin-8 AP-1 and kappa B-like sites are genetic end targets of FK506-sensitive pathway accompanied by calcium mobilization.
S.-I. Okamoto,Naofumi Mukaida,Kazuo Yasumoto,Nancy Rice,Yuji Ishikawa,Hyogo Horiguchi,Seishi Murakami,Koji Matsushima +7 more
TL;DR: The results indicate that not only the reported IL-2 NF-AT and NFIL-2A sites and Ig kappa B site are terminals of FK506-sensitive pathway involving Ca2+ mobilization.
141
Novel insight into molecular mechanism of endotoxin shock: biochemical analysis of LPS receptor signaling in a cell-free system targeting NF-kappaB and regulation of cytokine production/action through beta2 integrin in vivo.
Naofumi Mukaida,Yuji Ishikawa,Naoki Ikeda,Nakaba Fujioka,Shun Ichi Watanabe,Kouji Kuno,Koji Matsushima +6 more
TL;DR: In vivo administration of an anti‐CD18 antibody and an antibody to a ligand for CD18, intercellular adhesion molecule‐1, also prevented TNF‐induced shock as well as endotoxin shock in rabbits, suggesting that the interaction between leukoytes and endothelium through β2.
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Establishment of Lipopolysaccharide-dependent Nuclear Factor κB Activation in a Cell-free System
TL;DR: In this article, a cell-free system using plasma membrane-enriched, cytosol, and nuclear fractions extracted from a human monocytic cell line, THP-1, by disruption with sonication followed by a differential centrifugation was established.
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