Yuichi Yoshimura
Osaka University
29 Papers
109 Citations
Yuichi Yoshimura is an academic researcher from Osaka University. The author has contributed to research in topics: Chemistry & Amyloid. The author has an hindex of 16, co-authored 29 publications. Previous affiliations of Yuichi Yoshimura include Aarhus University & Hiroshima University.
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Papers
Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.
Teruhisa Tsuzuki,Y Fujii,Kunihiko Sakumi,Yohei Tominaga,Kazuki Nakao,Mutsuo Sekiguchi,Aizo Matsushiro,Yuichi Yoshimura,MoritaT +8 more
TL;DR: The mouse Rad51 gene is a mammalian homologue of the Escherichia coli recA and yeast RAD51 genes, both of which are involved in homologous recombination and DNA repair, which means that RAD51 protein plays an essential role in the proliferation of cell.
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Distinguishing crystal-like amyloid fibrils and glass-like amorphous aggregates from their kinetics of formation
Yuichi Yoshimura,Yuxi Lin,Hisashi Yagi,Young-Ho Lee,Hiroki Kitayama,Kazumasa Sakurai,Masatomo So,Hirotsugu Ogi,Hironobu Naiki,Yuji Goto +9 more
TL;DR: By monitoring the kinetics of the formation of amyloid fibrils and glass-like amorphous aggregates, it is shown that solubility and supersaturation will be key factors for further understanding the aberrant aggregation of proteins.
304
Ultrasonication-dependent production and breakdown lead to minimum-sized amyloid fibrils
TL;DR: It is presented that ultrasonication pulses are useful for preparing monodispersed amyloid fibrils of minimal size with an average molecular weight of ≈1,660,000 (140-mer).
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Acceleration of the depolymerization of amyloid β fibrils by ultrasonication.
TL;DR: The results indicate that, although amyloid fibrillation is a reversible process determined by thermodynamic stability, kinetically trapped supersaturation and physical difficulty of dissolving rigid fibrils prevent the smooth phase transitions.
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How internal cavities destabilize a protein
Mengjun Xue,Takuro Wakamoto,Camilla Kejlberg,Yuichi Yoshimura,Tania A. Nielsen,Michael W. Risør,Kristian W. Sanggaard,Ryo Kitahara,Frans A. A. Mulder +8 more
TL;DR: In this paper, the authors show how NMR spectroscopy, coupled with pressure perturbation, brings these elusive species to light, as pressure acts to favor states with lower partial molar volume.
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