Yuichi Mitsui
Osaka University
11 Papers
Yuichi Mitsui is an academic researcher from Osaka University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 5 publications.
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Papers
Polarization of M2 macrophages requires Lamtor1 that integrates cytokine and amino-acid signals.
Tetsuya Kimura,Shigeyuki Nada,Noriko Takegahara,Tatsusada Okuno,Satoshi Nojima,Satoshi Nojima,Sujin Kang,Sujin Kang,Daisuke Ito,Daisuke Ito,Keiko Morimoto,Keiko Morimoto,Takashi Hosokawa,Takashi Hosokawa,Yoshitomo Hayama,Yoshitomo Hayama,Yuichi Mitsui,Natsuki Sakurai,Hana Sarashina-Kida,Hana Sarashina-Kida,Masayuki Nishide,Masayuki Nishide,Yohei Maeda,Yohei Maeda,Hyota Takamatsu,Hyota Takamatsu,Daisuke Okuzaki,Masaki Yamada,Masato Okada,Atsushi Kumanogoh,Atsushi Kumanogoh +30 more
TL;DR: It is demonstrated that a lysosomal adaptor protein Lamtor1 plays an essential role in M2 polarization, coupling immunity and metabolism, and liver X receptor (LXR) is the downstream target of Lamtor 1 and mTORC1.
Dysregulated Expression of the Nuclear Exosome Targeting Complex Component Rbm7 in Nonhematopoietic Cells Licenses the Development of Fibrosis.
Kiyoharu Fukushima,Takashi Satoh,Takashi Satoh,Fuminori Sugihara,Yuki Sato,Toru Okamoto,Yuichi Mitsui,Sachiyo Yoshio,Songling Li,Satoshi Nojima,Daisuke Motooka,Shota Nakamura,Hiroshi Kida,Daron M. Standley,Eiichi Morii,Tatsuya Kanto,Motoko Yanagita,Yoshiharu Matsuura,Takashi Nagasawa,Atsushi Kumanogoh,Shizuo Akira +20 more
TL;DR: Rbm7 in epithelial cells plays a critical role in the development of fibrosis by regulating ncRNA decay and thereby the production of chemokines that recruit SatMs.
42
ETS1 governs pathological tissue-remodeling programs in disease-associated fibroblasts
Minglu Yan,Norio Komatsu,Ryunosuke Muro,Nam Cong-Nhat Huynh,Yoshihiko Tomofuji,Yukinori Okada,Hiroshi Suzuki,Hiroyuki Takaba,Riko Kitazawa,Sohei Kitazawa,Warunee Pluemsakunthai,Yuichi Mitsui,Takashi Satoh,Takashi Okamura,Takeshi Nitta,Sin-Hyeog Im,Chan Johng Kim,George Kollias,Sakae Tanaka,Kazuo Okamoto,Masayuki Tsukasaki,Hiroshi Takayanagi +21 more
TL;DR: This work identifies ETS1 as the key transcription factor governing the pathological tissue-remodeling programs in fibroblasts and provides a mechanistic basis for pathogenic fibroblast polarization and have important therapeutic implications.
35
CiDRE+ M2c macrophages hijacked by SARS-CoV-2 cause COVID-19 severity
Yuichi Mitsui,Tatsuya Suzuki,Kanako Kuniyoshi,Jun Inamo,Kensuke Yamaguchi,Mariko Komuro,Junya Watanabe,Mio Edamoto,Songling Li,Tsukasa Kouno,Seiya Oba,Tadashi Hosoya,Shohei Koyama,Nobuo Sakaguchi,Daron M. Standley,Jay W. Shin,Shizuo Akira,Shinsuke Yasuda,Yasunari Miyazaki,Yuta Kochi,Atsushi Kumanogoh,Toru Okamoto,Takashi Satoh +22 more
TL;DR: It is shown that interleukin-10 changed normal alveolar macrophage into ACE2-expressing M2c-type macrophages that functioned as spreading vectors for SARS-CoV-2 infection, and CiDRE inhibitors might be useful as COVID-19 therapies.
3
Proposal of a novel pipeline involving precise bronchoscopy of distal peripheral pulmonary lesions for genetic testing
So Takata,Kotaro Miyake,Daichi Maeda,Kazue Hatake,Izumi Nagatomo,Takayuki Shiroyama,Kentaro Masuhiro,Moto Yaga,Yuya Shirai,Yuichi Mitsui,Shinichi Yachida,Atsushi Kumanogoh +11 more
TL;DR: In this article , the authors proposed ultraselective biopsy (USB) with sample volume adjustment (SVA) as a novel method that integrates an ultrathin bronchoscope, radial probe endobronchial ultrasound, and the direct oblique method for ultrasensitive navigation, and adjustment of sample volume for NGS.