15 Papers
37 Citations
Yuhui Yan is an academic researcher from Liaoning University of Traditional Chinese Medicine. The author has contributed to research in topics: Neural stem cell & Neuroprotection. The author has an hindex of 9, co-authored 12 publications.
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Papers
Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease.
TL;DR: It is demonstrated that osthole plays a neuroprotective activity role in part through up-regulate miR-107 in AD, resulting in facilitating the cells survival, reducing LDH leakage, inhibiting apoptosis and reducing beta amyloid production in AD.
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Osthole promotes neuronal differentiation and inhibits apoptosis via Wnt/β-catenin signaling in an Alzheimer's disease model
Yingjia Yao,Zhong Gao,Wenbo Liang,Liang Kong,Yanan Jiao,Shaoheng Li,Zhenyu Tao,Yuhui Yan,Jingxian Yang +8 more
TL;DR: The mechanism underlying the effects of osthole on NSCs is investigated and it is found that osthole enhances NSC proliferation and neuronal differentiation while suppressing apoptosis, effects that were exerted via activation of Wnt/β-catenin signaling.
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Arctigenin Confers Neuroprotection Against Mechanical Trauma Injury in Human Neuroblastoma SH-SY5Y Cells by Regulating miRNA-16 and miRNA-199a Expression to Alleviate Inflammation.
Jie Song,Na Li,Yang Xia,Zhong Gao,Sa-feng Zou,Yuhui Yan,Shaoheng Li,Yue Wang,Ya-Kun Meng,Jingxian Yang,Tingguo Kang +10 more
TL;DR: Investigation of the capacity for arctigenin (ARC) to prevent secondary effects and the mechanism underlying the action of microRNA (miRNA)-199a and miRNA-16 in a mechanical trauma injury (MTI) model using SH-SY5Y cells in vitro provides insights into the pharmacological role of ARC in anti-inflammation and neuroprotection in neural cells.
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Osthole Protects Bone Marrow-Derived Neural Stem Cells from Oxidative Damage through PI3K/Akt-1 Pathway.
TL;DR: It is suggested that Ost protects BM-NSCs against oxidative stress injury, and it can be used to improve the inflammatory environment of neurodegenerative diseases so and promote the survival rate of transplanted NSCs.
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Osthole promotes endogenous neural stem cell proliferation and improved neurological function through Notch signaling pathway in mice acute mechanical brain injury.
Yuhui Yan,Liang Kong,Yang Xia,Wenbo Liang,Li-Tong Wang,Jie Song,Yingjia Yao,Ying Lin,Jingxian Yang +8 more
TL;DR: The findings support that Ost is a potential drug for treating MBI due to its neuronal restoration, and demonstrate that osthole (Ost), a natural coumarin derivative, was capable of promoting the proliferation of endogenous NSCs and improving neuronal restoration.
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