6 Papers
Yufei Chen is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: TFEB & Chemistry. The author has an hindex of 2, co-authored 5 publications.
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Papers
TFEB Mediates Immune Evasion and Resistance to mTOR Inhibition of Renal Cell Carcinoma via Induction of PD-L1.
Cai Zhang,Yaqi Duan,Minghui Xia,Yuting Dong,Yufei Chen,Lu Zheng,Shuaishuai Chai,Qian Zhang,Zhengping Wei,Na Liu,Jing Wang,Chaoyang Sun,Zhaohui Tang,Xiang Cheng,Jie Wu,Guo-Ping Wang,Fang Zheng,Arian Laurence,Bing Li,Xiang-Ping Yang +19 more
TL;DR: TFEB mediates resistance to mTOR inhibition via induction of PD-L1 in human primary RCC tumors, RCC cells, and murine xenograft model, providing a strong rationale to target mTOR and PD- L1 jointly as a novel immunotherapeutic approach for RCC treatment.
Regulation of T cell differentiation and function by epigenetic modification enzymes
Huicheng Liu,Pingfei Li,Pingfei Li,Zhengping Wei,Cai Zhang,Minghui Xia,Qiuyang Du,Yufei Chen,Na Liu,Huabin Li,Xiang-Ping Yang +10 more
TL;DR: The current literature about the functions of DNA and histone modification enzymes in T cell development, activation, differentiation, and function is reviewed.
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Transcription factor EB coordinates environmental cues to regulate T regulatory cells’ mitochondrial fitness and function
Minghui Xia,Cai Zhang,Yufei Chen,Xiujuan Zhao,Si Zhang,Yang Liu,You Cai,Zhengping Wei,Qiuyang Du,Wenting Yu,Chun Zhou,Hongjun Xiao,Guihua Wang,Xiang Cheng,Heng Mei,Arian Laurence,Jing Wang,Yu Hu,Hua-Bin Li,Xiang-Ping Yang +19 more
TL;DR: It is identified that transcription factor EB (TFEB) is induced by host nutrition deprivation or interleukin (IL)-2 in CD4+ T cells, which leads to reduced Treg accumulation and impaired Treg function in mouse models of cancer and autoimmune disease.
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ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages.
Pingfei Li,Xiaofei Deng,Jing Luo,Jing Luo,Yufei Chen,Guoyu Bi,Feili Gong,Zhengping Wei,Na Liu,Huabin Li,Arian Laurence,Xiang-Ping Yang +11 more
TL;DR: The restricted expression of ATP6V0d2 and its localization in lysosome membrane, whose expression is restricted in macrophages and inhibited by inflammatory stimuli and tumor cell-derived lactate, was speculated to play a role in amino acid-mediated mTORC1 activation in Macrophages.
Death-associated protein kinase 1 (DAPK1) controls CD8+ T cell activation, trafficking, and antitumor activity
Zhengping Wei,Qiuyang Du,Pingfei Li,Pingfei Li,Huicheng Liu,Minghui Xia,Yufei Chen,Guoyu Bi,Zhaohui Tang,Xiang Cheng,Youming Lu,Ran He,Arian Laurence,Jing Wang,Liu Huang,Huabin Li,Xiang-Ping Yang +16 more
TL;DR: Wang et al. as discussed by the authors found that inhibition of DAPK1 activity led to enhanced expression of the homing receptors CD62L and CCR7, and that deletion of either kinase domain or death domain in the T cell compartment reduced the T-cell activation and maintained the expression of CD62 l and cCR7.